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Michael M. Lederman

Researcher at Case Western Reserve University

Publications -  438
Citations -  37844

Michael M. Lederman is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 88, co-authored 424 publications receiving 35218 citations. Previous affiliations of Michael M. Lederman include University Hospitals of Cleveland & Rush University Medical Center.

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Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection : a case control study

Daniel D Murray, +1489 more
- 14 Oct 2015 - 
TL;DR: No associations with mortality were found with any circulating miRNAs studied and these results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection

TL;DR: It is shown that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation, which establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection.
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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells

TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
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The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

Florencia Pereyra, +336 more
- 10 Dec 2010 - 
TL;DR: Differences in binding to viral peptide antigens by HLA may be the major factors underlying genetic differences between HIV controllers and progressors, and genome-wide association results implicate the nature of the HLA–viral peptide interaction as the major factor modulating durable control of HIV infection.