M
Moniher Deb
Researcher at University of Pennsylvania
Publications - 2
Citations - 108
Moniher Deb is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 1, co-authored 2 publications receiving 28 citations.
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Journal ArticleDOI
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
Priyanka Verma,Yeqiao Zhou,Zhendong Cao,Peter V. Deraska,Moniher Deb,Eri Arai,Weihua Li,Yue Shao,Laura N. Puentes,Yiwen Li,Sonali Patankar,Robert H. Mach,Robert B. Faryabi,Junwei Shi,Roger A. Greenberg +14 more
TL;DR: Using a CRISPR-based screen, this article identified the PAR-binding chromatin remodeller ALC1/CHD1L as a key determinant of PARPi toxicity in HR-deficient cells.
Posted ContentDOI
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells
Priyanka Verma,Yeqiao Zhou,Zhendong Cao,Peter V. Deraska,Moniher Deb,Eri Arai,Weihua Li,Yue Shao,Yiwen Li,Laura N. Puentes,Sonali Patankar,Robert H. Mach,Robert B. Faryabi,Junwei Shi,Roger A. Greenberg +14 more
TL;DR: Using a CRISPR based screen, this work identifies the PAR-binding Snf2-like ATPase, ALC1/CHD1L, as a key determinant of PARPi toxicity in HR-deficient cells, and establishes PAR-dependent chromatin remodeling as a mechanistically distinct aspect ofPARPi responses, implicating A LC1 inhibition as a new approach to overcome therapeutic resistance in HR -deficient cancers.