P
Peter V. Deraska
Researcher at University of Pennsylvania
Publications - 4
Citations - 191
Peter V. Deraska is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Homologous recombination & Molecular beacon. The author has an hindex of 3, co-authored 4 publications receiving 49 citations.
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Journal ArticleDOI
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
Priyanka Verma,Yeqiao Zhou,Zhendong Cao,Peter V. Deraska,Moniher Deb,Eri Arai,Weihua Li,Yue Shao,Laura N. Puentes,Yiwen Li,Sonali Patankar,Robert H. Mach,Robert B. Faryabi,Junwei Shi,Roger A. Greenberg +14 more
TL;DR: Using a CRISPR-based screen, this article identified the PAR-binding chromatin remodeller ALC1/CHD1L as a key determinant of PARPi toxicity in HR-deficient cells.
Journal ArticleDOI
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons.
Scott Sherrill-Mix,Young Hwang,Aoife M. Roche,Abigail L. Glascock,Susan R. Weiss,Yize Li,Leila Haddad,Peter V. Deraska,Caitlin Monahan,Andrew Kromer,Jevon Graham-Wooten,Louis J. Taylor,Benjamin S. Abella,Arupa Ganguly,Ronald G. Collman,Gregory D. Van Duyne,Frederic D. Bushman +16 more
TL;DR: In this paper, the authors describe the design and testing of molecular beacons, which allow sequence-specific detection of SARS-CoV-2 genomes with improved discrimination in simple reaction mixtures.
Posted ContentDOI
LAMP-BEAC: Detection of SARS-CoV-2 RNA Using RT-LAMP and Molecular Beacons
Scott Sherrill-Mix,Young Hwang,Aoife M. Roche,Abigail L. Glascock,Susan R. Weiss,Yize Li,Leila Haddad,Peter V. Deraska,Caitlin Monahan,Andrew Kromer,Jevon Graham-Wooten,Louis J. Taylor,Benjamin S. Abella,Arupa Ganguly,Ronald G. Collman,Gregory D. Van Duyne,Frederic D. Bushman +16 more
TL;DR: The design and testing of molecular beacons are described, which allow sequence-specific detection of SARS-CoV-2 genomes with improved discrimination in simple reaction mixtures and how beacons with different fluorescent labels can allow convenient multiplex detection of several amplicons in "single pot" reactions.
Posted ContentDOI
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells
Priyanka Verma,Yeqiao Zhou,Zhendong Cao,Peter V. Deraska,Moniher Deb,Eri Arai,Weihua Li,Yue Shao,Yiwen Li,Laura N. Puentes,Sonali Patankar,Robert H. Mach,Robert B. Faryabi,Junwei Shi,Roger A. Greenberg +14 more
TL;DR: Using a CRISPR based screen, this work identifies the PAR-binding Snf2-like ATPase, ALC1/CHD1L, as a key determinant of PARPi toxicity in HR-deficient cells, and establishes PAR-dependent chromatin remodeling as a mechanistically distinct aspect ofPARPi responses, implicating A LC1 inhibition as a new approach to overcome therapeutic resistance in HR -deficient cancers.