Yeqiao Zhou

TL;DR: Mapping chromatin looping genome-wide in Notch-dependent triple-negative breast cancer and B cell lymphoma shows that beyond the well-characterized role of Notch as an activator of distal enhancers, Notch regulates its direct target genes by instructing enhancer repositioning and suggests that oncogenic hijacking of developmental transcription factors can dysregulate transcription through widespread effects on the spatial organization of cancer genomes.

TL;DR: Using a CRISPR-based screen, this article identified the PAR-binding chromatin remodeller ALC1/CHD1L as a key determinant of PARPi toxicity in HR-deficient cells.

TL;DR: These findings provide key insights into the role of Notch in MCL and other B cell malignancies and have important implications for therapeutic targeting of notch-dependent oncogenic pathways.

TL;DR: The TooManyCells approach to scRNA-seq data facilitates efficient and unbiased identification and visualization of cell clades and rare subpopulations and enables multiresolution and multifaceted exploration of single-cell clades.

TL;DR: 3D genome mapping of NODxC57BL/6 F1 thymocytes revealed that genomic misfolding in NOD mice is mediated in cis, and immune cells infiltrating the pancreas of humans with T1D exhibited increased expression of genes located on misfolded loci in mice.