G
Georges M. G. M. Verjans
Researcher at Erasmus University Rotterdam
Publications - 146
Citations - 4856
Georges M. G. M. Verjans is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Virus & Varicella zoster virus. The author has an hindex of 37, co-authored 140 publications receiving 4054 citations. Previous affiliations of Georges M. G. M. Verjans include University of Washington & University of Veterinary Medicine Hanover.
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Journal ArticleDOI
Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia.
Georges M. G. M. Verjans,Rogier Q. Hintzen,Jessica M. van Dun,Angelique Poot,Johannes C M Milikan,Jon D. Laman,Anton W. Langerak,Paul R. Kinchington,Albert D. M. E. Osterhaus +8 more
TL;DR: The results implicate that herpesvirus latency in human TG is associated with a local, persistent T cell response, comprising activated late effector memory CD8+ T cells that appear to control HSV-1 latency by noncytolytic pathways.
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Neurotropic virus infections as the cause of immediate and delayed neuropathology.
Martin Ludlow,Jeroen Kortekaas,Christiane Herden,Bernd Hoffmann,Dennis Tappe,Corinna Trebst,Diane E. Griffin,Hannah Brindle,Tom Solomon,Alan S. Brown,Debby van Riel,Katja C. Wolthers,Dasja Pajkrt,Peter Wohlsein,Byron E. E. Martina,Wolfgang Baumgärtner,Georges M. G. M. Verjans,Georges M. G. M. Verjans,Albert D. M. E. Osterhaus,Albert D. M. E. Osterhaus +19 more
TL;DR: Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world.
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Epstein Barr virus is not a characteristic feature in the central nervous system in established multiple sclerosis
Laura A. N. Peferoen,F. Lamers,L.N.R. Lodder,Wouter H. Gerritsen,Inge Huitinga,Jeroen Melief,Gavin Giovannoni,Ute-Christiane Meier,R Q Hintzen,Georges M. G. M. Verjans,G.P. van Nierop,W. Vos,Regina Peferoen-Baert,Jaap M. Middeldorp,P. van der Valk,Sandra Amor,Sandra Amor +16 more
TL;DR: It is shown that there is little evidence for the presence of EBV in the central nervous system of people with multiple sclerosis, and the studies reveal the vagaries of pathological detection methods for infectious agents such as EBV.
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T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early intervention
Jamie van Langelaar,Roos M van der Vuurst de Vries,Malou Janssen,Annet F Wierenga-Wolf,Isis M Spilt,Theodora A Siepman,Wendy Dankers,Georges M. G. M. Verjans,Georges M. G. M. Verjans,Helga E. de Vries,Erik Lubberts,Rogier Q. Hintzen,Marvin M van Luijn +12 more
TL;DR: Findings reveal a dominant contribution of Th1-like Th17 subpopulations, in particular Th17.1 cells, to clinical disease activity and provide a strong rationale for more specific and earlier use of T cell-targeted therapy in multiple sclerosis.
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IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts.
TL;DR: The data presented suggest that IL-17 may play an important role in the induction and/or perpetuation of the immunopathologic processes in human HSK by modulating the secretion of proinflammatory and neutrophil chemotactic factors by corneal resident fibroblasts.