M
Morihisa Hirota
Researcher at Tohoku University
Publications - 95
Citations - 3839
Morihisa Hirota is an academic researcher from Tohoku University. The author has contributed to research in topics: Pancreatitis & Acute pancreatitis. The author has an hindex of 33, co-authored 87 publications receiving 3387 citations.
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Journal ArticleDOI
Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015.
Masamichi Yokoe,Tadahiro Takada,Toshihiko Mayumi,Masahiro Yoshida,Shuji Isaji,Keita Wada,Takao Itoi,Naohiro Sata,Toshifumi Gabata,Hisato Igarashi,Keisho Kataoka,Masahiko Hirota,Masumi Kadoya,Nobuya Kitamura,Yasutoshi Kimura,Seiki Kiriyama,Kunihiro Shirai,Takayuki Hattori,Kazunori Takeda,Yoshifumi Takeyama,Morihisa Hirota,Miho Sekimoto,Satoru Shikata,Shinju Arata,Koichi Hirata +24 more
TL;DR: Japanese (JPN) guidelines for the management of acute pancreatitis were published in 2006, and following the 2012 revision of the Atlanta Classifications of Acute Pancreatitis, the development of a minimally invasive method for local complications of pancreatitis spread was developed.
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Expression of survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors.
Kennichi Satoh,Kenzo Kaneko,Morihisa Hirota,Atsushi Masamune,Akihiko Satoh,Tooru Shimosegawa +5 more
TL;DR: This work has shown that survivin, a new member of the inhibitor of apoptosis family of antiapoptotic proteins, was expressed selectively in all the most common human carcinomas but not in normal adult tissues.
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Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.
Atsushi Masamune,Kazuhiro Kikuta,Takashi Watanabe,Kennichi Satoh,Morihisa Hirota,Tooru Shimosegawa +5 more
TL;DR: In conclusion, hypoxia induced profibrogenic and proangiogenic responses in PSCs, suggesting that P SCs might play proangIogenic roles during the development of pancreatic fibrosis, where they are subjected to Hypoxia.
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Nationwide epidemiological survey of autoimmune pancreatitis in Japan.
Atsushi Kanno,Isao Nishimori,Atsushi Masamune,Kazuhiro Kikuta,Morihisa Hirota,Shinichi Kuriyama,Ichiro Tsuji,Tooru Shimosegawa +7 more
TL;DR: From the results, most AIP patients in Japan can be categorized to type 1 AIP according to the recent classification of AIP.
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Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells.
Shin Hamada,Atsushi Masamune,Tetsuya Takikawa,Noriaki Suzuki,Kazuhiro Kikuta,Morihisa Hirota,Hirofumi Hamada,Masayoshi Kobune,Kennichi Satoh,Tooru Shimosegawa +9 more
TL;DR: Indirect co-culture of pancreatic cancer cells with PSCs enhanced the spheroid-forming ability of cancer cells and induced the expression of cancer stem cell-related genes ABCG2, Nestin and LIN28, which suggested a novel role of P SCs as a part of the cancer stem Cell niche.