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Shinji Kamisuki
Researcher at Azabu University
Publications - 89
Citations - 2051
Shinji Kamisuki is an academic researcher from Azabu University. The author has contributed to research in topics: DNA polymerase & Chemistry. The author has an hindex of 23, co-authored 81 publications receiving 1807 citations. Previous affiliations of Shinji Kamisuki include University of Tokyo & Tokyo University of Science.
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Journal ArticleDOI
A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP
Shinji Kamisuki,Qian Mao,Lutfi Abu-Elheiga,Zi-Wei Gu,Akira Kugimiya,Youngjoo Kwon,Tokuyuki Shinohara,Yoshinori Kawazoe,Shinichi Sato,Koko Asakura,Hea Young Park Choo,Juro Sakai,Salih J. Wakil,Motonari Uesugi,Motonari Uesugi +14 more
TL;DR: The analysis suggests that fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain.
Journal Article
[Discovering high-affinity ligands for proteins: SAR by NMR].
Shinji Kamisuki,Motonari Uesugi +1 more
Journal ArticleDOI
Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin.
Shinichi Sato,Youngjoo Kwon,Shinji Kamisuki,Neeta Srivastava,Qian Mao,Yoshinori Kawazoe,Yoshinori Kawazoe,Motonari Uesugi,Motonari Uesugi +8 more
TL;DR: The results indicate that insertion of a long, rigid polyproline helix between a small-molecule bait and a biotin tag boosts the capacity of affinity purification and thereby permits isolation of low-abundance or low-affinity proteins.
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A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide
Manabu Kaneko,Koichi Watashi,Koichi Watashi,Shinji Kamisuki,Hiroki Matsunaga,Masashi Iwamoto,Masashi Iwamoto,Fumihiro Kawai,Hirofumi Ohashi,Hirofumi Ohashi,Senko Tsukuda,Satomi Shimura,Ryosuke Suzuki,Hideki Aizaki,Masaya Sugiyama,Sam-Yong Park,Takayoshi Ito,Naoko Ohtani,Fumio Sugawara,Yasuhito Tanaka,Masashi Mizokami,Camille Sureau,Takaji Wakita +22 more
TL;DR: A fungal metabolite, vanitaracin A, is identified, which was a potent, well-tolerated, and broadly active inhibitor of HBV and HDV entry and could be part of an antiviral strategy for preventing reinfection with HBV, including clinically relevant nucleos(t)ide analog-resistant virus.
Journal ArticleDOI
A Plant Phytotoxin, Solanapyrone A, Is an Inhibitor of DNA Polymerase β and λ
Yoshiyuki Mizushina,Shinji Kamisuki,Nobuyuki Kasai,Noriko Shimazaki,Masaharu Takemura,Hitomi Asahara,Stuart Linn,Shonen Yoshida,Akio Matsukage,Osamu Koiwai,Fumio Sugawara,Hiromi Yoshida,Kengo Sakaguchi +12 more
TL;DR: The inhibitory mechanism of solanapyrone A inhibited the single-stranded DNA-binding activity but did not influence the activities of the 5′-phosphate recognition in gapped DNA structures and the AP lyase.