M
Muhammed A. Yildirim
Researcher at Harvard University
Publications - 70
Citations - 7550
Muhammed A. Yildirim is an academic researcher from Harvard University. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 20, co-authored 41 publications receiving 6622 citations. Previous affiliations of Muhammed A. Yildirim include Howard Hughes Medical Institute & California Institute of Technology.
Papers
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Journal ArticleDOI
Drug—target network
Muhammed A. Yildirim,Kwang-Il Goh,Kwang-Il Goh,Kwang-Il Goh,Michael E. Cusick,Albert-László Barabási,Albert-László Barabási,Albert-László Barabási,Marc Vidal +8 more
TL;DR: A bipartite graph composed of US Food and Drug Administration–approved drugs and proteins linked by drug–target binary associations is built, showing an overabundance of 'follow-on' drugs, that is, drugs that target already targeted proteins.
Journal ArticleDOI
High-Quality Binary Protein Interaction Map of the Yeast Interactome Network
Haiyuan Yu,Pascal Braun,Muhammed A. Yildirim,Irma Lemmens,Kavitha Venkatesan,Julie M. Sahalie,Tomoko Hirozane-Kishikawa,Fana Gebreab,Nan Li,Nicolas Simonis,Tong Hao,Jean François Rual,Amélie Dricot,Alexei Vazquez,Ryan R. Murray,Christophe Simon,Leah Tardivo,Stanley Tam,Nenad Svrzikapa,Changyu Fan,Anne-Sophie De Smet,Adriana Motyl,Michael E. Hudson,Juyong Park,Juyong Park,Xiaofeng Xin,Michael E. Cusick,Troy Moore,Charles Boone,Michael Snyder,Frederick P. Roth,Albert-László Barabási,Albert-László Barabási,Jan Tavernier,David E. Hill,Marc Vidal +35 more
TL;DR: A comparative quality assessment of current yeast interactome data sets is carried out, demonstrating that high-throughput yeast two-hybrid (Y2H) screening provides high-quality binary interaction information.
Journal ArticleDOI
An empirical framework for binary interactome mapping
Kavitha Venkatesan,Kavitha Venkatesan,Jean François Rual,Alexei Vazquez,Alexei Vazquez,Ulrich Stelzl,Irma Lemmens,Tomoko Hirozane-Kishikawa,Tong Hao,Martina Zenkner,Xiaofeng Xin,Kwang-Il Goh,Kwang-Il Goh,Kwang-Il Goh,Muhammed A. Yildirim,Nicolas Simonis,Kathrin Heinzmann,Fana Gebreab,Julie M. Sahalie,Sebiha Cevik,Sebiha Cevik,Christophe Simon,Anne Sophie de Smet,Elizabeth Dann,Alex Smolyar,Arunachalam Vinayagam,Haiyuan Yu,David Szeto,Heather Borick,Heather Borick,Amélie Dricot,Niels Klitgord,Niels Klitgord,Ryan R. Murray,Chenwei Lin,Maciej Lalowski,Jan Timm,Kirstin Rau,Charles Boone,Pascal Braun,Michael E. Cusick,Frederick P. Roth,David E. Hill,Jan Tavernier,Erich E. Wanker,Albert-László Barabási,Albert-László Barabási,Marc Vidal +47 more
TL;DR: The results indicate that high-throughput yeast two-hybrid interactions for human proteins are more precise than literature-curated interactions supported by a single publication, suggesting that HT-Y2H is suitable to map a significant portion of the human interactome.
BookDOI
The Atlas of Economic Complexity : Mapping Paths to Prosperity
Ricardo Hausmann,César A. Hidalgo,Sebastián Bustos,Michele Coscia,Alex Simoes,Muhammed A. Yildirim +5 more
TL;DR: The Atlas of Economic Complexity as discussed by the authors is a tool to measure the amount of productive knowledge countries hold and how they can move to accumulate more of it by making more complex products.
Journal ArticleDOI
Proto-genes and de novo gene birth
Anne-Ruxandra Carvunis,Thomas Rolland,Ilan Wapinski,Michael A. Calderwood,Muhammed A. Yildirim,Nicolas Simonis,Nicolas Simonis,Benoit Charloteaux,Benoit Charloteaux,César A. Hidalgo,Justin Barbette,Balaji Santhanam,Gloria A. Brar,Jonathan S. Weissman,Aviv Regev,Aviv Regev,Nicolas Thierry-Mieg,Michael E. Cusick,Marc Vidal +18 more
TL;DR: In this article, the authors formalize an evolutionary model according to which functional genes evolve de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.