N
Niels Klitgord
Researcher at Boston University
Publications - 38
Citations - 8455
Niels Klitgord is an academic researcher from Boston University. The author has contributed to research in topics: Interactome & Microbiome. The author has an hindex of 25, co-authored 38 publications receiving 7674 citations. Previous affiliations of Niels Klitgord include Harvard University & Bio-Rad Laboratories.
Papers
More filters
Journal ArticleDOI
Towards a proteome-scale map of the human protein–protein interaction network
Jean François Rual,Kavitha Venkatesan,Tong Hao,Tomoko Hirozane-Kishikawa,Amélie Dricot,Ning Li,Gabriel F. Berriz,Francis D. Gibbons,Matija Dreze,Nono Ayivi-Guedehoussou,Niels Klitgord,Christophe Simon,Mike Boxem,Stuart Milstein,Jennifer Rosenberg,Debra S. Goldberg,Lan V. Zhang,Sharyl L. Wong,Giovanni Franklin,Siming Li,Joanna S. Albala,Joanna S. Albala,Janghoo Lim,Carlene Fraughton,Estelle Llamosas,Sebiha Cevik,Camille Bex,Philippe Lamesch,Robert S. Sikorski,Jean Vandenhaute,Huda Y. Zoghbi,Alex Smolyar,Stephanie Bosak,Reynaldo Sequerra,Lynn Doucette-Stamm,Michael E. Cusick,David E. Hill,Frederick P. Roth,Marc Vidal +38 more
TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.
Journal ArticleDOI
An empirical framework for binary interactome mapping
Kavitha Venkatesan,Kavitha Venkatesan,Jean François Rual,Alexei Vazquez,Alexei Vazquez,Ulrich Stelzl,Irma Lemmens,Tomoko Hirozane-Kishikawa,Tong Hao,Martina Zenkner,Xiaofeng Xin,Kwang-Il Goh,Kwang-Il Goh,Kwang-Il Goh,Muhammed A. Yildirim,Nicolas Simonis,Kathrin Heinzmann,Fana Gebreab,Julie M. Sahalie,Sebiha Cevik,Sebiha Cevik,Christophe Simon,Anne Sophie de Smet,Elizabeth Dann,Alex Smolyar,Arunachalam Vinayagam,Haiyuan Yu,David Szeto,Heather Borick,Heather Borick,Amélie Dricot,Niels Klitgord,Niels Klitgord,Ryan R. Murray,Chenwei Lin,Maciej Lalowski,Jan Timm,Kirstin Rau,Charles Boone,Pascal Braun,Michael E. Cusick,Frederick P. Roth,David E. Hill,Jan Tavernier,Erich E. Wanker,Albert-László Barabási,Albert-László Barabási,Marc Vidal +47 more
TL;DR: The results indicate that high-throughput yeast two-hybrid interactions for human proteins are more precise than literature-curated interactions supported by a single publication, suggesting that HT-Y2H is suitable to map a significant portion of the human interactome.
Journal ArticleDOI
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease
Rohit Loomba,Victor Seguritan,Weizhong Li,Tao Long,Niels Klitgord,Archana Bhatt,Parambir S. Dulai,Cyrielle Caussy,Richele Bettencourt,Sarah K. Highlander,Marcus B. Jones,Claude B. Sirlin,Bernd Schnabl,Lauren M. Brinkac,Nicholas J. Schork,Chi-Hua Chen,David A. Brenner,William H. Biggs,Shibu Yooseph,J. Craig Venter,Karen E. Nelson +20 more
TL;DR: Preliminary evidence is provided for a fecal-microbiome-derived metagenomic signature to detect advanced fibrosis in nonalcoholic fatty liver disease.
Journal ArticleDOI
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes.
Chad Haynes,Christopher J. Oldfield,Fei Ji,Niels Klitgord,Michael E. Cusick,Predrag Radivojac,Vladimir N. Uversky,Vladimir N. Uversky,Marc Vidal,Lilia M. Iakoucheva +9 more
TL;DR: The results of this study demonstrate that intrinsic structural disorder is a distinctive and common characteristic of eukaryotic hub proteins, and that disorder may serve as a determinant of protein interactivity.
Journal ArticleDOI
Interactome: gateway into systems biology
TL;DR: Although far from complete, currently available maps provide insight into how biochemical properties of proteins and protein complexes are integrated into biological systems, and are also a useful resource to predict the function(s) of thousands of genes.