M
Mukesh Samant
Researcher at Kumaun University
Publications - 56
Citations - 1250
Mukesh Samant is an academic researcher from Kumaun University. The author has contributed to research in topics: Leishmania donovani & Visceral leishmaniasis. The author has an hindex of 19, co-authored 48 publications receiving 889 citations. Previous affiliations of Mukesh Samant include Council of Scientific and Industrial Research & Laval University.
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Immunization with the DNA-encoding N-terminal domain of proteophosphoglycan of Leishmania donovani generates Th1-type immunoprotective response against experimental visceral leishmaniasis.
Mukesh Samant,Reema Gupta,Shraddha Kumari,Pragya Misra,Prashant Khare,Pramod K. Kushawaha,Amogh A. Sahasrabuddhe,Anuradha Dube +7 more
TL;DR: The results suggest the N-terminal domain of L. donovani ppg as a potential DNA vaccine against visceral leishmaniasis as well as golden hamsters against the L.Donovani challenge.
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Vaccination strategies to combat novel corona virus SARS-CoV-2.
TL;DR: Various vaccine candidates i.e., nucleotide, subunit and vector based as well as attenuated and inactivated forms, which have already been demonstrated their prophylactic efficacy against MERS-CoV and SARS- coV are summarized so these candidates could be used as a potential tool for the development of a safe and effective vaccine against SARS -CoV-2.
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In vitro and in vivo leishmanicidal activity of Dysoxylum binectariferum and its fractions against Leishmania donovani.
TL;DR: The leishmanicidal effect of crude ethanolic extract of stem bark of Dysoxylum binectariferum and its fractions has been investigated against Leishmania donovani and the pure compound, rohitukine, showed weaker in vitro activity and was ineffective in infected hamsters.
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Bioremediation: an emerging effective approach towards environment restoration
TL;DR: The metabolic potential of microbes has tremendously improved the realization of degradation and remediation of environmental pollution and recent advances in microbes and plants associated bioremediation are discussed.
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Th1-stimulatory polyproteins of soluble Leishmania donovani promastigotes ranging from 89.9 to 97.1 kDa offers long-lasting protection against experimental visceral leishmaniasis.
Shraddha Kumari,Mukesh Samant,Pragya Misra,Prashant Khare,Brijesh S. Sisodia,Ajit Kumar Shasany,Anuradha Dube +6 more
TL;DR: Protection was obtained in hamsters vaccinated with pooled subfractions with remarkable lymphoproliferative, IFN-gamma and IL-12 responses along with profound delayed type hypersensitivity and increased levels of Leishmania-specific IgG2 antibody suggesting that a successful subunit vaccine against VL may require multiple Th1-immunostimulatory proteins.