Showing papers by "Murlidhar S. Shingare published in 2010"
TL;DR: In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and fungi Candida albicans and Aspergillus niger and some of the tested compounds showed significant antimicrobial activity.
110 citations
TL;DR: Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2, 3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) has been achieved in very high yield.
84 citations
TL;DR: In this paper, a one-pot three-component condensation of an aldehyde, malononitrile, and thiophenol has been achieved by conventional and ultrasound method.
71 citations
TL;DR: Ammonium metavanadate (NH 4 VO 3 ) has been shown to be an inexpensive, efficient, and mild catalyst for the one-pot synthesis of octahydroquinazolinone derivatives using dimedone, urea/thiourea, and appropriate aromatic aldehydes under microwave-irradiation as mentioned in this paper.
46 citations
TL;DR: Triethylammonium acetate (TEAA) ionic liquid catalyzed one pot synthesis of 6-amino-4-aryl-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles.
33 citations
TL;DR: Polyethylene glycol-400 has been found to be a recyclable and rapid reaction medium for the synthesis of 2-amino-4H-chromenes by the condensation of aromatic aldehyde, malononitrile, and α-naphthol as discussed by the authors.
Abstract: Polyethylene glycol-400 has been found to be a recyclable and rapid reaction medium for the synthesis of 2-amino-4H-chromenes by the condensation of aromatic aldehyde, malononitrile, and α-naphthol. This method gives remarkable advantages such as simple work up, high yields, and a greener method by avoiding toxic catalyst and hazardous solvents.
32 citations
TL;DR: Cl 2 /AlCl 3 has been used for the synthesis of octahydroquinazolinone derivatives under ultrasound-irradiation as mentioned in this paper, which provides several advantages such as environment benign, high yields and simple work-up procedure.
Abstract: Acidic ionic liquid [tbmim]Cl 2 /AlCl 3 catalysed an efficient synthesis of octahydroquinazolinone derivatives under ultrasound-irradiation. This method provides several advantages such as environment benign, high yields and simple work-up procedure.
31 citations
TL;DR: In this article, the condensation of several aromatic/hetero-aromatic aldehydes with 2-aminothiophenol catalyzed by silica sulfuric acid under microwave irradiation afforded 2-arylbenzothiazoles in high yields and short reaction times under solvent free conditions.
Abstract: The condensation of several aromatic/heteroaromatic aldehydes with 2-aminothiophenol catalyzed by silica sulfuric acid under microwave irradiation afforded 2-arylbenzothiazoles in high yields and short reaction times under sol-vent-free conditions. The major advantages of the present method are good yields, ecofriendly, reusable catalyst, mild and solvent-free reaction conditions.
30 citations
TL;DR: In this paper, a simple, rapid and highly efficient method has been attempted for the three-component condensation of benzil/benzoin, aldehydes, and ammonium acetate under microwave irradiation in the presence of a catalytic amount of bio-supported cellulose sulfuric acid under solvent-free conditions to afford the 2,4,5-triarylimidazole derivatives.
Abstract: A simple, rapid, and highly efficient method has been attempted for the three-component condensation of benzil/benzoin, aldehydes, and ammonium acetate under microwave irradiation in the presence of a catalytic amount of bio-supported cellulose sulfuric acid under solvent-free conditions to afford the 2,4,5-triarylimidazole derivatives. The catalyst is easily prepared, inexpensive, separated simply by filtration, gives excellent yield of products with shorter reaction times, and is recyclable several times.
29 citations
TL;DR: 1-Hexanesulphonic acid sodium salt was found to be an efficient catalyst for the green synthesis of alpha-aminophosphonates by the coupling of aldehydes/ketone, an amine and triethyl phosphite under ultrasound irradiation at ambient temperature for appropriate time to furnish the desired product in good to excellent yield under solvent-free condition.
27 citations
TL;DR: In this paper, the authors used KAl(SO4)2·12H2O as an inexpensive, efficient, and non-toxic catalyst for the synthesis of 5-arylidine-2,4-thiazolidinediones.
Abstract: Alum (KAl(SO4)2·12H2O) is an inexpensive, efficient, and non-toxic catalyst used for the synthesis of 5-arylidine-2,4-thiazolidinediones by the Knoevenagel condensation of aromatic aldehydes with 2,4-thiazolidinedione in aqueous media at 90°C. This method affords the 5-arylidine-2,4-thiazolidinediones in short reaction times, high yields, and green aspects by avoiding toxic catalysts and hazardous solvents.
TL;DR: In this paper, a one-pot synthesis of new 3,4-dihydro-3-substituted 2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-Naphthol, various anilines and formalin at room temperature grinding is presented.
Abstract: †An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity.
TL;DR: In this paper, a simple, efficient, and practical procedure for the synthesis of various substituted 2,3-dihydro-2-phenyl-1H-naphtho[1,2-e][1,3]oxazines using KAl(SO4)2 12H2O (alum) as a non-toxic, reusable, inexpensive, and easily available catalyst is described using water as a solvent.
Abstract: A simple, efficient, and practical procedure for the synthesis of various substituted 2,3-dihydro-2-phenyl-1H-naphtho[1,2-e][1,3]oxazines and 3,4-dihydro-3-phenyl-2H-naphtho[2,1-e][1,3]oxazines using KAl(SO4)2 12H2O (alum) as a non-toxic, reusable, inexpensive, and easily available catalyst is described using water as a solvent. These improved reaction conditions allow the preparation of a wide variety of substituted [1,3]oxazines in high yields and purity under mild reaction conditions.
TL;DR: Alum (KAl(SO4)2·12H2O) was used as a novel catalyst for the synthesis of anthraquinone derivatives from phthalic anhydride and substituted benzenes in good to excellent yields (70-96%) using water as a solvent at ambient temperature as mentioned in this paper.
Abstract: Alum (KAl(SO4)2·12H2O) performs as a novel catalyst for the synthesis of anthraquinone derivatives from phthalic anhydride and substituted benzenes in good to excellent yields (70–96%) using water as a solvent at ambient temperature. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The remarkable advantages offered by this method are an inexpensive and easily available catalyst, a simple procedure, mild conditions, and much faster (60–120 min) reactions.
TL;DR: Heterogeneous catalyst aluminium oxide (acidic) was found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yields as mentioned in this paper.
TL;DR: An efficient and simplified protocol for NaHSO 4 /SiO 2 catalyzed solvent-free synthesis of β-enaminone and 2-methyl-quinolin-4( 1H)-one derivatives under microwave irradiation is described in this paper.
Abstract: An efficient and simplified protocol for NaHSO 4 /SiO 2 catalyzed solvent-free synthesis of β-enaminone and 2-methyl-quinolin-4( 1H)-one derivatives under microwave irradiation is described. A series of functionalized derivatives have been synthesized in shorter reaction times with moderate to good yields. The use of milder catalyst in non-conventional method offers significant advantages over conventional methods, such as higher selectivities, simplicity, solvent-free reaction and non-environmental polluting conditions.
TL;DR: In this article, a series of new tetrazolo[1,5a]quinoline derivatives were synthesized for the first time via 4-carbonitrile derivatives, which showed significant antimicrobial activity against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi.
Abstract: A series of new tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives were synthesized for the first time via tetrazolo[1,5-a]quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data were used to elucidate the structures of all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi, Candida albicans and Aspergillus niger, in comparison with standard drugs. Some of the tested compounds showed significant antimicrobial activity.
TL;DR: In this article, a series of new alpha-hydroxyphosphonate and alpha-acetoxyphosphotonate derivatives have been synthesized for the first time of tetrazolo quinoline derivatives.
Abstract: A series of new alpha-hydroxyphosphonate and alpha-acetoxyphosphonate derivatives have been synthesized for the first time of tetrazolo [1, 5-a] quinoline derivatives. Elemental analysis, IR, (1)H NMR, (13)C NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of the synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and fungi Candida albicans and Aspergillus niger. Some of the tested compounds showed significant antimicrobial activity.
TL;DR: Nickel nanoparticles (Ni NPs) appeared to exhibit the catalytic activity in one-pot cyclocondensation reaction for the preparation of 3,4-dihydropyrimidine-2(1H)-ones via Biginelli reaction from aromatic/hetero-aromatic/aliphatic aldehydes, urea/thiourea and ethyl acetoacetate under microwave irradiation has been described as discussed by the authors.
Abstract: Nickel nanoparticles (Ni NPs) appeared to exhibit the catalytic activity in one-pot cyclocondensation reaction for the preparation of 3,4-dihydropyrimidine-2(1H)-ones via Biginelli reaction from aromatic/heteroaromatic/aliphatic aldehydes, urea/thiourea and ethyl acetoacetate under microwave irradiation has been described. The UV absorbance spectra showed metallic Ni characteristics and appreciate with the particle size determined by Transmission electron microscopy (TEM). After reaction course the Ni NPs can be re-covered and reused without any apparent loss of activity.
TL;DR: In this article, all newly synthesized derivatives of the previously unknown heterocyclic system (V) were screened for their antimicrobial activity and the results showed that they were all positive.
TL;DR: In this paper, Br/basic alumina (Al 2 O 3 ) has been found to promote cyclocondensation of chloroacetone/chloroethyl acetate with salicylaldehydes under conventional and microwave irradiation to yield benzofuran derivatives.
TL;DR: In this paper, a phase transfer catalyst (PTC) was used as a mild reaction promoter for the cyclocondensation of formalin, β-naphthol and aromatic amines to afford respective 2,3-dihydro-2-phenyl-1H-Naphtho-[1,2-e] [1,3] oxazine derivatives.
Abstract: Sodium hydrogen sulphate (NaHS0 4 ), n-tetra butyl ammonium bromide (TBAB) as a phase transfer catalyst (PTC) in water, and 1-butyl-3-methyl imidazolium hydrogen sulphate [bmim]HS0 4 as ionic liquid (IL) has been used as a mild reaction promoter for the cyclocondensation of formalin, β-naphthol and aromatic amines to afford respective 2,3-dihydro-2-phenyl-1H-naphtho-[1,2-e] [1,3] oxazine derivatives. The present protocols are greener, high yielding and involved the non-chromatographic isolation procedure.
TL;DR: A series of diethyl (4-fluorophenylamino) (substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphonate derivatives has been synthesized for the first time from tetrazological quinoline derivatives, and microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity.
Abstract: A series of diethyl (4-fluorophenylamino) (substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphonate derivatives has been synthesized for the first time from tetrazolo [1,5-a] quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly, microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
TL;DR: Shinde et al. as discussed by the authors synthesized 1-Benzofuran-2-yl thiadiazoles, Triazoles and Oxadiazole using cyclocondensation of thiosemicarbazides.
Abstract: . The synthesis of benzofuran based 1,3,4-thiadiazoles, 1, 3,4-triazoles and 1,3,4-oxadiazole via cyclocondensation of thiosemicarbazides have been carried out by conventional and non-conventional methods in excellent yields of product. Keywords: Thiosemicarbazide, Thiadiazoles, Triazoles, Oxadiazoles, Microwave and Ultrasound irradiation 반응방법에 따른 1-Benzofuran-2-yl thiadiazoles, Triazoles과 Oxadiazoles의 합성 Ananta D. Shinde, Bhima Y. Kale, Bapurao B. Shingate, and Murlidhar S. Shingare * Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, M.S. India. (접수 2010. 1. 12; 수정 2010. 2. 23; 게재확정 2010. 5. 4) Synthesis and Characterization of 1-Benzofuran-2-yl thiadiazoles, Triazoles and Oxadiazoles by Conventional and Non-conventional Methods Ananta D. Shinde, Bhima Y. Kale, Bapurao B. Shingate, and Murlidhar S. Shingare * Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, M.S. India. * E-mail: prof_msshingare@rediffmail.com
01 Feb 2010
TL;DR: In this article, an efficient and novel one-pot synthesis of 3,4-dihydro-3-substituted-2 H -naphtho[2,1- e ][1,3]oxazine derivatives from 1 naphthol, various anilines and formalin at room temperature stirring was presented.
Abstract: An efficient and novel one-pot synthesis of 3,4-dihydro-3-substituted-2 H -naphtho[2,1- e ][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature stirring. The six-membered N,O-heterocyclic skeleton was constructed via 1-benzyl-3-methyl imidazolium hydrogen sulphate [bnmim] [HSO 4 ] promoted Mannich type reaction. Keywords : 1,3-oxazines; ionic liquid; Mannich type reaction; multicomponent reaction. 1. Introduction Multicomponent reactions (MCRs), defined as one pot reactions in which at least three functional groups join through covalent bonds, have been steadily gaining importance in synthetic organic chemistry. 1-4 The reagents employed may be different molecules or they may be different molecules or they may be different functional groups of the same reagent. Speed, diversity, efficiency and environmental amiability are some of the key features of this class of reactions. Ionic liquids (ILs) have aroused considerable interest over the past decade due to their wide variety of properties. In this regard, they can be used as solvents and reaction supports.
TL;DR: The first successful lithium bromide mediated solvent free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields is described in this article.
TL;DR: In this article, the synthesis of novel thiadiazole, selenadiazoles, and spirocyclic benzopyrans via the semicarbazides 3 and thiosemicarbazide 3 of 2-ethyl-2-methyl-4H-chromen-4-ones by conventional and nonconventional methods was described.
Abstract: We describe the synthesis of novel thiadiazole, selenadiazole, and spirocyclic benzopyrans via the semicarbazides 3 and thiosemicarbazides 3 of 2-ethyl-2-methyl-4H-chromen-4-ones 1 by conventional and nonconventional methods. The microwave and ultrasonic irradiation methods form the respective products in excellent yields in very short reaction time as compared to the conventional method. The synthesized compounds were tested for antimicrobial screening against bacteria and fungi show moderate activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.
TL;DR: In this article, a green, mild and efficient method for Knoevenagel condensation of 3-formylchromone/2-chlroquinoline-3-carbaldehyde with active methylene compounds such as Meldrum's acid/ethyl cyanoacetate using biosupported cellulose sulphuric acid (CSA) in the solid-state by grinding under solvent-free condition has been developed.
Abstract: A green, mild and efficient method for Knoevenagel condensation of 3-formylchromone/2-chlroquinoline-3-carbaldehyde with active methylene compounds such as Meldrum’s acid/ethyl cyanoacetate using biosupported cellulose sulphuric acid (CSA) in the solid-state by grinding under solvent-free condition has been developed. This method provides several advantages including environmental friendliness, shor t reaction times, high yields and a simple work-up procedure. Moreover, the CSA was successfully reused for four cycles without significant loss of activity.
TL;DR: Some new 4,5-diphenyl-1H-imidazole derivatives were synthesized in good yields by treating various tetrazolo[1,5a]quinolines with benzil and ammonium acetate in glacial acetic acid as discussed by the authors.
Abstract: Some new 4,5-diphenyl-1H-imidazole derivatives were synthesized in good yields by treating various tetrazolo[1,5-a]quinolines with benzil and ammonium acetate in glacial acetic acid.