Protic Ionic Liquids: Properties and Applications

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

Organic Chemistry By Dr. I. L. Finar. Vol. 2: Stereochemistry and the Chemistry of Natural Products. Pp. xi + 733. (London and New York: Longmans, Green and Co., Ltd., 1956.) 40s. net.

Advanced Organic Chemistry

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201100432

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

3.1.2. Huisgen [3 + 2] Cycloaddition Reaction 6313 3.1.3. Claisen Rearrangement 6315 3.2. Multicomponent Reactions 6316 3.3. Nucleophilic Ring-Opening Reactions 6316 3.4. Wittig Reaction 6318 3.5. Bioorthogonal Reactions 6318 4. Catalyzed Reactions 6319 4.1. Metal-Catalyzed Reactions 6319 4.1.1. Pericyclic Reactions 6320 4.1.2. Arylation Reactions 6321 4.1.3. Olefin Metathesis 6323 4.1.4. Mizoroki-Heck Reaction 6324 4.1.5. Suzuki Reaction 6325 4.1.6. Sonogashira Reaction 6327 4.1.7. Transfer Hydrogenation 6327 4.1.8. Lewis Acid Catalysis 6328 4.2. Organocatalyzed Reactions 6330 4.2.1. Pericyclic Reactions 6330 4.2.2. Michael Reaction 6331 4.2.3. Mannich Reaction 6332 4.2.4. Aldol Reaction 6333 5. Conclusion 6334 6. Supporting Information Available 6335 7. References 6335

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

Morpholinium bisulfate [morH][HSO4] found to be highly inexpensive, efficient, and reusable catalyst to promote the acylation of phenols, thiols, alcohols, and amines in presence of acetic anhydride under solvent-free condition with excellent yields by stirring at room temperature. Present methodology deals with remarkable features of mild reaction condition, high yielding, shorter reaction time, easy workup, and more importantly, environmentally benign.

Morpholinium bisulfate [morH][HSO4]-promoted O, S, and Nacylation at room temperature

Synthesis of Bis(indolyl) Methanes Using Aluminum Oxide (Acidic) in Dry Media.

A rapid, solvent-free and environmentally friendly Knoevenagel condensation reaction of 4-oxo-(4H)-1-bcnzopyran-3-carbaldehyde 1 with Meldrum's acid 2 has been carried out under microwave irradiation. The structures of condensed products 3a-g have been characterized on the basis of IR and 1 H NMR spectral data.

/pdf/microwave-induced-solvent-free-knoevenagel-condensation-of-4-5cpdg0hf4v.pdf

Microwave induced, solvent-free Knoevenagel condensation of 4-oxo-(4H)-1-benzopyran -3 -carbaldehyde with Meldrum's acid using alumina support

An Efficient Synthesis of 2,4,5‐Triaryl‐1H‐imidazole Derivatives Catalyzed by Boric Acid in Aqueous Media under Ultrasound‐Irradiation.

The synthetic strategy toward highly functionalized pyridines succeeds efficiently for aryl aldehydes, but with significantly lower yields if aliphatic aldehydes are involved.

Murlidhar S. Shingare

Papers

Morpholinium bisulfate [morH][HSO4]-promoted O, S, and Nacylation at room temperature

Synthesis of Bis(indolyl) Methanes Using Aluminum Oxide (Acidic) in Dry Media.

Microwave induced, solvent-free Knoevenagel condensation of 4-oxo-(4H)-1-benzopyran -3 -carbaldehyde with Meldrum's acid using alumina support

An Efficient Synthesis of 2,4,5‐Triaryl‐1H‐imidazole Derivatives Catalyzed by Boric Acid in Aqueous Media under Ultrasound‐Irradiation.

Sodium Chloride: A Proficient Additive for the Synthesis of Pyridine Derivatives in Aqueous Medium.