Protic Ionic Liquids: Properties and Applications

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

Organic Chemistry By Dr. I. L. Finar. Vol. 2: Stereochemistry and the Chemistry of Natural Products. Pp. xi + 733. (London and New York: Longmans, Green and Co., Ltd., 1956.) 40s. net.

Advanced Organic Chemistry

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201100432

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

3.1.2. Huisgen [3 + 2] Cycloaddition Reaction 6313 3.1.3. Claisen Rearrangement 6315 3.2. Multicomponent Reactions 6316 3.3. Nucleophilic Ring-Opening Reactions 6316 3.4. Wittig Reaction 6318 3.5. Bioorthogonal Reactions 6318 4. Catalyzed Reactions 6319 4.1. Metal-Catalyzed Reactions 6319 4.1.1. Pericyclic Reactions 6320 4.1.2. Arylation Reactions 6321 4.1.3. Olefin Metathesis 6323 4.1.4. Mizoroki-Heck Reaction 6324 4.1.5. Suzuki Reaction 6325 4.1.6. Sonogashira Reaction 6327 4.1.7. Transfer Hydrogenation 6327 4.1.8. Lewis Acid Catalysis 6328 4.2. Organocatalyzed Reactions 6330 4.2.1. Pericyclic Reactions 6330 4.2.2. Michael Reaction 6331 4.2.3. Mannich Reaction 6332 4.2.4. Aldol Reaction 6333 5. Conclusion 6334 6. Supporting Information Available 6335 7. References 6335

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

An Organocatalyzed Expeditious Synthetic Route to Tetrahydrobenzo[a]xanthen‐11‐ones via Grinding Technique.

An oxidative deblocking procedure of aldoximes using FeCl 3 and ketoximes using SeO 2 in aprotic solvent is reported. Reaction yields are competitive as compared to previous methods. Reactions are easy to work and conditions are mild. Some important features of FeCl 3 are mentioned.

/pdf/selective-regeneration-of-carbonyl-compounds-from-aldoximes-269sfjl6pi.pdf

Selective regeneration of carbonyl compounds from aldoximes and ketoximes, catalyzed by FeCl 3 and SeO 2

Synthesis of 1,4‐Dihydropyridines and Their Hypotensive Activity.

The combination of stannous chloride and ionic liquid is crucial for a successful rearrangement and scarcely any reaction occurs when either SnCl2 or the given ionic liquid are absent.

Microwave‐Assisted Beckmann Rearrangement of Ketoximes Using Stannous(II) Chloride in Ionic Liquid as an Efficient Catalyst.

All newly synthesized derivatives of the previously unknown heterocyclic system (V) are screened for their antimicrobial activity.

Murlidhar S. Shingare

Papers

An Organocatalyzed Expeditious Synthetic Route to Tetrahydrobenzo[a]xanthen‐11‐ones via Grinding Technique.

Selective regeneration of carbonyl compounds from aldoximes and ketoximes, catalyzed by FeCl 3 and SeO 2

Synthesis of 1,4‐Dihydropyridines and Their Hypotensive Activity.

Microwave‐Assisted Beckmann Rearrangement of Ketoximes Using Stannous(II) Chloride in Ionic Liquid as an Efficient Catalyst.

Synthesis and Antibacterial Screening of New 4-((5-(Difluoromethoxy)-1H-benzo[d]imidazol-2-ylthio)methyl)tetrazolo [1,5-a]quinoline Derivatives.