Protic Ionic Liquids: Properties and Applications

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

Organic Chemistry By Dr. I. L. Finar. Vol. 2: Stereochemistry and the Chemistry of Natural Products. Pp. xi + 733. (London and New York: Longmans, Green and Co., Ltd., 1956.) 40s. net.

Advanced Organic Chemistry

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201100432

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

3.1.2. Huisgen [3 + 2] Cycloaddition Reaction 6313 3.1.3. Claisen Rearrangement 6315 3.2. Multicomponent Reactions 6316 3.3. Nucleophilic Ring-Opening Reactions 6316 3.4. Wittig Reaction 6318 3.5. Bioorthogonal Reactions 6318 4. Catalyzed Reactions 6319 4.1. Metal-Catalyzed Reactions 6319 4.1.1. Pericyclic Reactions 6320 4.1.2. Arylation Reactions 6321 4.1.3. Olefin Metathesis 6323 4.1.4. Mizoroki-Heck Reaction 6324 4.1.5. Suzuki Reaction 6325 4.1.6. Sonogashira Reaction 6327 4.1.7. Transfer Hydrogenation 6327 4.1.8. Lewis Acid Catalysis 6328 4.2. Organocatalyzed Reactions 6330 4.2.1. Pericyclic Reactions 6330 4.2.2. Michael Reaction 6331 4.2.3. Mannich Reaction 6332 4.2.4. Aldol Reaction 6333 5. Conclusion 6334 6. Supporting Information Available 6335 7. References 6335

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

dihydro-1-aryl naphtho (1,2-e) (1,3) oxazine-3-one derivatives have been synthesized via one-pot condensation of aromatic aldehyde, β-naphthol and urea using cellulose sulfuric acid (CSA) as catalyst in solvent free condition under microwave irradiation. CSA has efficiently catalyzed the cyclocon - densation and enhanced the product yields by reducing reaction time. The uniqueness of CSA is that it is isolable after the reaction and reusable.

/pdf/environmentally-benign-protocol-for-the-synthesis-of-1-2-kqc9jywnkf.pdf

Environmentally Benign Protocol for the Synthesis of 1,2-dihydro-1-aryl naph- tho (1,2-e) (1,3) oxazine-3-one Derivatives.

Synthesis and Characterization of Some Novel 2‐{2‐[1‐(3‐Substitutedphenyl)‐1H‐1,2,3‐triazol‐4‐yl‐] ethyl}‐1‐substituted‐1H‐benzo[d]imidazole Derivatives.

Optimized reaction conditions are developed which avoid the use of toxic phosphine ligands.

An Efficient Method for the N‐Arylation of Phenylurea via Copper‐Catalyzed Amidation.

The transformation with nitrile esters must be carried out in the absence of LiBr; otherwise, formation of by-products is observed.

Murlidhar S. Shingare

Papers

Environmentally Benign Protocol for the Synthesis of 1,2-dihydro-1-aryl naph- tho (1,2-e) (1,3) oxazine-3-one Derivatives.

Synthesis and Characterization of Some Novel 2‐{2‐[1‐(3‐Substitutedphenyl)‐1H‐1,2,3‐triazol‐4‐yl‐] ethyl}‐1‐substituted‐1H‐benzo[d]imidazole Derivatives.

An Efficient Method for the N‐Arylation of Phenylurea via Copper‐Catalyzed Amidation.

Lithium Bromide Catalyzed Solvent-Free Method for the Synthesis of 2-Substituted Benzimidazoles and Imidazopyridines.

Synthesis of New O,O-Dialkyl-O-coumarinophosphorothioates and Their Pesticidal Bioassay Against Helicoverpa armigera.