Protic Ionic Liquids: Properties and Applications

Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions

Organic Chemistry By Dr. I. L. Finar. Vol. 2: Stereochemistry and the Chemistry of Natural Products. Pp. xi + 733. (London and New York: Longmans, Green and Co., Ltd., 1956.) 40s. net.

Advanced Organic Chemistry

The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/asia.201100432

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores

3.1.2. Huisgen [3 + 2] Cycloaddition Reaction 6313 3.1.3. Claisen Rearrangement 6315 3.2. Multicomponent Reactions 6316 3.3. Nucleophilic Ring-Opening Reactions 6316 3.4. Wittig Reaction 6318 3.5. Bioorthogonal Reactions 6318 4. Catalyzed Reactions 6319 4.1. Metal-Catalyzed Reactions 6319 4.1.1. Pericyclic Reactions 6320 4.1.2. Arylation Reactions 6321 4.1.3. Olefin Metathesis 6323 4.1.4. Mizoroki-Heck Reaction 6324 4.1.5. Suzuki Reaction 6325 4.1.6. Sonogashira Reaction 6327 4.1.7. Transfer Hydrogenation 6327 4.1.8. Lewis Acid Catalysis 6328 4.2. Organocatalyzed Reactions 6330 4.2.1. Pericyclic Reactions 6330 4.2.2. Michael Reaction 6331 4.2.3. Mannich Reaction 6332 4.2.4. Aldol Reaction 6333 5. Conclusion 6334 6. Supporting Information Available 6335 7. References 6335

Water: Nature’s Reaction Enforcer—Comparative Effects for Organic Synthesis “In-Water” and “On-Water”

Ammonium metavanadate as an efficient catalyst for the synthesis of 2,4,5‐triaryl‐1H‐imidazoles

A unique product of 1;2 Shift, Beckmann reaction has it’s good many synthesis application. Beckmann reaction is a general tool in organic chemistry. The reaction requires high reaction temperature; strong acidic conditions and dehydrating media. Amides are important biological and commercial compounds. Because amide constitutes the backbone of protein molecules, their chemistry is of extreme importance. The penicillin and cephalosporin antibiotics are among the best-known products of the pharmaceutical industry. Keep all such things in mind we go for preparation of anilides, which also contribute excellent role to synthesis, various organic compounds. The Beckmann rearrangement requires strong acidic conditions such as conc. Sulphuric acid or Phosphoric acid these have a large amount of side products and serious corrosion problems. So, In recent days the milder conditions were tried and investigated on clean, simple, ecofriendly benign and excellent process became the chemists interesting undertaking. Several improved or developed process are reported using modified reagents and solid acid catalyst like clay, zeolites and silica sulfuric acid. However, the reactions are sluggish when they are performed in the liquid phase. Relatively few solid phase methods have been developed. Also the Beckman reaction using a Stoichiometic amount of cynuric chloride and Dimethyl formamide salt, Reactions was observed with solvents other than Dimethyl formamide and the reaction rate decreased noticeably with a reduced amount of cyanuric chloride in Dimethyl formamide. Also some methods are available for one-pot Beckmann reaction of Acetophenone (ketone). Hence, overcome all such disadvantages we report clean, effective, and simple method for one-pot synthesis of anilides in presence of catalytic amount of silica supported Sulphamic acid using microwave irradiation under solvent free condition.

/pdf/silica-supported-sulphamic-acid-as-mild-catalyst-for-55mi5ap3u7.pdf

Murlidhar S. Shingare

Papers

Ammonium metavanadate as an efficient catalyst for the synthesis of 2,4,5‐triaryl‐1H‐imidazoles

Silica Supported Sulphamic Acid as Mild Catalyst for Synthesis of Anilides (Beckmann Rearrangement), Using Microwave Irradiation

Microwave accelerated tetrahydropyranylation and detetrahydropyranylation of alcohols, phenols, and thiols catalyzed by hydrated zirconia

A Novel Approach for Ligand Promoted Palladium (II)-Catalyzed Suzuki Coupling of Aryl Iodides and Bromides with Arylboronic Acid in Aqueous Media

Novel, efficient, and green procedure for the synthesis of 1,5-benzodiazepines catalyzed by MgBr2 in aqueous media