Muthana Al Abo

TL;DR: It is concluded that SLFN11 is recruited to stressed replication forks carrying extended RPA filaments where it blocks replication by changing chromatin structure across replication sites.

TL;DR: Wild-type FANCA was also subject to SUMOylation, RNF4-mediated polyubiquitination, and degradation, suggesting that regulated release of FAAP20 from FAN CA is a critical step in the normal FA pathway.

TL;DR: The essential role played by both the BRCA1-PALB2-BRCA2 complex and the DBD in the functionality of BRC a2 is revealed, as each can compensate for the other in the recruitment of B RCA2 to DNA-damage sites.

TL;DR: The importance of TDP1 is identified as a novel determinant of response to CNDAC across various cancer types (especially non–small cell lung cancers), and the differential involvement of BRCA2, PARP1, and T DP1 in the cellular responses to C NDAC, AraC, and CPT is demonstrated.

TL;DR: It is found that short exons are more likely to be mis-spliced and preferentially excluded in cancers, and a CASE-based panel is developed as reliable cancer stratification markers and strong predictors for survival, clinically useful because the detection of short exon splicing is practical.