M
Myoung Ho Jang
Researcher at Pohang University of Science and Technology
Publications - 81
Citations - 7651
Myoung Ho Jang is an academic researcher from Pohang University of Science and Technology. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 35, co-authored 78 publications receiving 6872 citations. Previous affiliations of Myoung Ho Jang include Osaka University.
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Journal ArticleDOI
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Tatsuya Saitoh,Naonobu Fujita,Myoung Ho Jang,Satoshi Uematsu,Bo-Gie Yang,Takashi Satoh,Hiroko Omori,Takeshi Noda,Naoki Yamamoto,Masaaki Komatsu,Masaaki Komatsu,Masaaki Komatsu,Keiji Tanaka,Taro Kawai,Tohru Tsujimura,Osamu Takeuchi,Tamotsu Yoshimori,Shizuo Akira +17 more
TL;DR: It is shown that Atg16L1 (autophagy-related 16-like 1), which is implicated in Crohn's disease, regulates endotoxin-induced inflammasome activation in mice and is an essential component of the autophagic machinery responsible for control of the endot toxin-induced inflammatory immune response.
Journal ArticleDOI
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Satoshi Uematsu,Kosuke Fujimoto,Myoung Ho Jang,Bo-Gie Yang,Yun-Jae Jung,Mika Nishiyama,Shintaro Sato,Tohru Tsujimura,Masafumi Yamamoto,Yoshifumi Yokota,Hiroshi Kiyono,Masayuki Miyasaka,Ken Ishii,Shizuo Akira +13 more
TL;DR: These findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine and positively regulated the differentiation interleukin 17–producing T helper cells.
Journal ArticleDOI
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Satoshi Uematsu,Myoung Ho Jang,Nicolas Chevrier,Zijin Guo,Yutaro Kumagai,Masahiro Yamamoto,Hiroki Kato,Nagako Sougawa,Hidenori Matsui,Hirotaka Kuwata,Hiroaki Hemmi,Cevayir Coban,Taro Kawai,Ken Ishii,Osamu Takeuchi,Masayuki Miyasaka,Kiyoshi Takeda,Shizuo Akira +17 more
TL;DR: It is suggested that CD11c+ LPCs, via TLR5, detect and are used by pathogenic bacteria in the intestinal lumen, as suggested in Tlr5−/− mice.
Journal ArticleDOI
Intestinal villous M cells: An antigen entry site in the mucosal epithelium
Myoung Ho Jang,Mi-Na Kweon,Mi-Na Kweon,Mi-Na Kweon,Koichi Iwatani,Masafumi Yamamoto,Masafumi Yamamoto,Masafumi Yamamoto,Kazutaka Terahara,Chihiro Sasakawa,Toshihiko Suzuki,Tomonori Nochi,Yoshifumi Yokota,Paul D. Rennert,Takachika Hiroi,Takachika Hiroi,Hiroshi Tamagawa,Hideki Iijima,Jun Kunisawa,Jun Kunisawa,Yoshikazu Yuki,Hiroshi Kiyono +21 more
TL;DR: A distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which are designated intestinal villous M cells.
Journal ArticleDOI
CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes.
Myoung Ho Jang,Nagako Sougawa,Toshiyuki Tanaka,Takako Hirata,Takachika Hiroi,Kazuo Tohya,Zijin Guo,Eiji Umemoto,Yukihiko Ebisuno,Bo-Gie Yang,Ju Young Seoh,Martin Lipp,Hiroshi Kiyono,Masayuki Miyasaka +13 more
TL;DR: It is strongly suggested that LP-DCs with unique immunomodulatory activities migrate to MLNs in a CCR7-dependent manner to engage in the presentation of IEC-associated Ags acquired in the LP.