M
Myriam Cramet
Researcher at Laval University
Publications - 4
Citations - 333
Myriam Cramet is an academic researcher from Laval University. The author has contributed to research in topics: Nucleosome & Histone code. The author has an hindex of 4, co-authored 4 publications receiving 293 citations.
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Journal ArticleDOI
NuA4-dependent Acetylation of Nucleosomal Histones H4 and H2A Directly Stimulates Incorporation of H2A.Z by the SWR1 Complex *
Mohammed Altaf,Andréanne Auger,Julie Monnet-Saksouk,Joëlle Brodeur,Sandra Piquet,Myriam Cramet,Nathalie Bouchard,Nicolas Lacoste,Rhea T. Utley,Luc Gaudreau,Jacques Côté +10 more
TL;DR: The impact of NuA4-dependent acetylation on SWR1-driven incorporation of H2A.Z into chromatin is investigated, and depletion experiments indicate that the bromodomain-containing protein Bdf1 is important for NuA 4-dependent stimulation ofSWR1.
Journal ArticleDOI
Structure and nucleosome interaction of the yeast NuA4 and Piccolo–NuA4 histone acetyltransferase complexes
Johnathan Chittuluru,Yuriy Chaban,Julie Monnet-Saksouk,Michael J. Carrozza,Vasileia Sapountzi,William Selleck,Jiehuan Huang,Rhea T. Utley,Myriam Cramet,Stéphane Allard,Gang Cai,Jerry L. Workman,Michael Fried,Song Tan,Jacques Côté,Francisco J. Asturias +15 more
TL;DR: EM and biochemistry are used to characterize the structure of NuA4, an essential yeast histone acetyltransferase (HAT) complex conserved throughout eukaryotes, and the interaction of Nu a4 with the nucleosome core particle (NCP) is determined.
Journal ArticleDOI
Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling
Dorine Rossetto,Myriam Cramet,Alice Y. Wang,Anne-Lise Steunou,Nicolas Lacoste,Julia M. Schulze,Valérie Côté,Julie Monnet-Saksouk,Sandra Piquet,Amine Nourani,Michael S. Kobor,Jacques Côté +11 more
TL;DR: A model where Eaf5/7/3 associates with elongating polymerase to promote the disruption of nucleosomes in its path, but also their refolding in its wake is proposed, supporting a role in nucleosome destabilization.
Journal ArticleDOI
Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome
Anne-Lise Steunou,Myriam Cramet,Dorine Rossetto,Maria J. Aristizabal,Nicolas Lacoste,Simon Drouin,Valérie Côté,Eric Paquet,Rhea T. Utley,Nevan J. Krogan,François Robert,Michael S. Kobor,Jacques Côté +12 more
TL;DR: These results argue that methylated histone reader modules in NuA4 are not responsible for its recruitment to the promoter or coding regions but, rather, are required to orient its acetyltransferase catalytic site to the methylatedhistone 3-bearing nucleosomes in the surrounding chromatin, cooperating to allow proper transition from transcription initiation to elongation.