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N L Sharma
Researcher at University of Oxford
Publications - 35
Citations - 1754
N L Sharma is an academic researcher from University of Oxford. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 16, co-authored 32 publications receiving 1502 citations. Previous affiliations of N L Sharma include University of Cambridge & John Radcliffe Hospital.
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Journal ArticleDOI
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Charles E. Massie,Andy G. Lynch,Antonio Ramos-Montoya,Joan Boren,Rory Stark,Ladan Fazli,Anne Y. Warren,H Scott,Basetti Madhu,N L Sharma,Helene Bon,Vinny Zecchini,D. Smith,Gina M. DeNicola,Nik Mathews,Michelle Osborne,James Hadfield,Stewart MacArthur,Boris Adryan,Scott K. Lyons,Kevin M. Brindle,John R. Griffiths,Martin E. Gleave,Paul S. Rennie,David E. Neal,Ian G. Mills +25 more
TL;DR: Cal calcium/calmodulin‐dependent protein kinase kinase 2 is highlighted, which it is shown is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone‐dependent modulator of anabolic metabolism.
Journal ArticleDOI
The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man
N L Sharma,Charles E. Massie,Antonio Ramos-Montoya,Vincent Zecchini,H Scott,Alastair D. Lamb,Stewart MacArthur,Rory Stark,Anne Y. Warren,Ian G. Mills,David E. Neal +10 more
TL;DR: A 16 gene signature that outperformed a larger in-vitro-derived signature in clinical data sets is identified, showing the importance of persistent AR signaling in CRPC.
Journal ArticleDOI
Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study
Helen Ross-Adams,Alastair D. Lamb,Mark J Dunning,Silvia Halim,Johan Lindberg,C M Massie,Lars Egevad,Roslin Russell,Antonio Ramos-Montoya,Sarah L. Vowler,N L Sharma,Jonathan Kay,Hayley C. Whitaker,Jeremy Clark,Rachel Hurst,Vincent J. Gnanapragasam,Nimish Shah,Anne Y. Warren,Cyrus Cooper,Andy G. Lynch,Rory Stark,Ian G. Mills,Henrik Grönberg,David E. Neal +23 more
TL;DR: For the first time in prostate cancer this study demonstrates the importance of integrated genomic analyses incorporating both benign and tumour tissue data in identifying molecular alterations leading to the generation of robust gene sets that are predictive of clinical outcome in independent patient cohorts.
Journal ArticleDOI
Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair.
TL;DR: The current evidence for the use of HDACi in combination with irradiation is explored, focusing on the effects of histone deacetylases on DNA damage signalling and repair in vitro and on a growing area of interest with great potential clinical utility.
Journal ArticleDOI
HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E2F1‐mediated cell cycle network
Antonio Ramos-Montoya,Alastair D. Lamb,Roslin Russell,Thomas L. Carroll,Sarah Jurmeister,Nuria Galeano-Dalmau,Charles E. Massie,Joan Boren,Helene Bon,Vasiliki Theodorou,Maria Vias,Greg Shaw,N L Sharma,Helen Ross-Adams,H Scott,Sarah L. Vowler,William J. Howat,Anne Y. Warren,Richard F. Wooster,Ian G. Mills,Ian G. Mills,David E. Neal +21 more
TL;DR: It is shown for the first time the critical role of HES6 in the development of CRPC and its potential in patient‐specific therapeutic strategies.