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Antonio Ramos-Montoya
Researcher at University of Barcelona
Publications - 23
Citations - 1512
Antonio Ramos-Montoya is an academic researcher from University of Barcelona. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 14, co-authored 21 publications receiving 1288 citations. Previous affiliations of Antonio Ramos-Montoya include Norwich University.
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Journal ArticleDOI
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Charles E. Massie,Andy G. Lynch,Antonio Ramos-Montoya,Joan Boren,Rory Stark,Ladan Fazli,Anne Y. Warren,H Scott,Basetti Madhu,N L Sharma,Helene Bon,Vinny Zecchini,D. Smith,Gina M. DeNicola,Nik Mathews,Michelle Osborne,James Hadfield,Stewart MacArthur,Boris Adryan,Scott K. Lyons,Kevin M. Brindle,John R. Griffiths,Martin E. Gleave,Paul S. Rennie,David E. Neal,Ian G. Mills +25 more
TL;DR: Cal calcium/calmodulin‐dependent protein kinase kinase 2 is highlighted, which it is shown is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone‐dependent modulator of anabolic metabolism.
Journal ArticleDOI
The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man
N L Sharma,Charles E. Massie,Antonio Ramos-Montoya,Vincent Zecchini,H Scott,Alastair D. Lamb,Stewart MacArthur,Rory Stark,Anne Y. Warren,Ian G. Mills,David E. Neal +10 more
TL;DR: A 16 gene signature that outperformed a larger in-vitro-derived signature in clinical data sets is identified, showing the importance of persistent AR signaling in CRPC.
Journal ArticleDOI
Pentose phosphate cycle oxidative and nonoxidative balance: A new vulnerable target for overcoming drug resistance in cancer.
Antonio Ramos-Montoya,Wai-Nang Paul Lee,Sara Bassilian,Shu Lim,Raisa V. Trebukhina,Maria V. Kazhyna,Carlos J. Ciudad,Véronique Noé,Josep J. Centelles,Marta Cascante +9 more
TL;DR: The vulnerability of cancer cells to the imbalance on pentose phosphate cycle was demonstrated by phenotypic phase plane analysis and the robustness of cancer cell metabolism was demonstrated.
Journal ArticleDOI
A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy
Nelma Pértega-Gomes,Sérgio Luis Felisbino,Charles E. Massie,José Ramón Vizcaíno,Ricardo Marques Coelho,Chiranjeevi Sandi,Susana Simões-Sousa,Sarah Jurmeister,Antonio Ramos-Montoya,Mohammad Asim,Maxine G. B. Tran,Elsa Oliveira,Alexandre Lobo da Cunha,Valdemar Máximo,Valdemar Máximo,Fátima Baltazar,David E. Neal,Lee G. D. Fryer +17 more
TL;DR: It is suggested that patients with highly glycolytic tumours have poorer outcome, supporting the notion of targeting glycoleytic tumour cells in prostate cancer through the use of MCT inhibitors.
Journal ArticleDOI
The early effects of rapid androgen deprivation on human prostate cancer
Greg Shaw,Hayley C. Whitaker,Marie Corcoran,Mark J Dunning,Hayley J. Luxton,Jonathan Kay,Charles E. Massie,Jodi Miller,Alastair D. Lamb,Helen Ross-Adams,Roslin Russell,Adam W Nelson,Matthew D. Eldridge,Andy G. Lynch,Antonio Ramos-Montoya,Ian G. Mills,Ian G. Mills,Angela E Taylor,Wiebke Arlt,Nimish Shah,Anne Y. Warren,David E. Neal,David E. Neal +22 more
TL;DR: This first-in-man study defines the rapid gene expression changes taking place in prostate cancer (PCa) following castration as upregulation of oestrogen receptor 1 is a mechanism by which PCa cells may survive despite castration.