N
N Philippe
Researcher at Pasteur Institute
Publications - 38
Citations - 2742
N Philippe is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Acute lymphocytic leukemia & Bone marrow. The author has an hindex of 21, co-authored 38 publications receiving 2645 citations.
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Journal ArticleDOI
Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency
Despina Moshous,Isabelle Callebaut,Régina de Chasseval,Barbara Corneo,Marina Cavazzana-Calvo,Françoise Le Deist,Ilhan Tezcan,Ozden Sanal,Yves Bertrand,N Philippe,Alain Fischer,Jean-Pierre de Villartay +11 more
TL;DR: The cloning of the gene encoding a novel protein involved in V(D)J recombination/DNA repair, Artemis, whose mutations cause human RS-SCID is described.
Journal ArticleDOI
Comparison of Escherichia coli-asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer-Children's Leukemia Group phase 3 trial.
Michel Duval,Stefan Suciu,Alina Ferster,Xavier Rialland,Brigitte Nelken,Patrick Lutz,Yves Benoit,Alain Robert,Anne-Marie Manel,Etienne Vilmer,Jacques Otten,N Philippe +11 more
TL;DR: With the dose scheduling used in this protocol, E coli-asparaginase induced more coagulation abnormalities but was superior to Erwinia-asParaginase for the treatment of childhood lymphoid malignancies.
Journal ArticleDOI
Partial albinism with immunodeficiency (Griscelli syndrome)
Christoph Klein,N Philippe,Françoise Le Deist,Sylvie Fraitag,Catherine Prost,Anne Durandy,Alain Fischer,Claude Griscelli +7 more
TL;DR: It is concluded that partial albinism with immunodeficiency (Griscelli syndrome) can be differentiated from Chédiak-Higashi syndrome by pathognomonic histologic features.
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Day-care, early common infections and childhood acute leukaemia: a multicentre French case-control study.
Florence Perrillat,Jacqueline Clavel,Marie-Françoise Auclerc,André Baruchel,Guy Leverger,Brigitte Nelken,N Philippe,Gilbert Schaison,Danièle Sommelet,Etienne Vilmer,Denis Hémon +10 more
TL;DR: The results support Greaves' hypothesis, even though they are not specific of common leukaemia, and the role of early infections in the aetiology of childhood acute leukaemias is investigated.
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High-dose chemoradiotherapy with bone marrow transplantation as consolidation treatment in neuroblastoma: an unselected group of stage IV patients over 1 year of age.
Thierry Philip,J L Bernard,Jean-Michel Zucker,Ross Pinkerton,Patrick Lutz,Pierre Bordigoni,Emmanuel Plouvier,Annie Robert,R Carton,N Philippe +9 more
TL;DR: Since January 1983, 56 consecutive children over 1 year of age with stage IV neuroblastoma entered an aggressive protocol, including chemotherapy, radiation therapy, and bone marrow transplantation, including platinum and epipodophyllotoxin.