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Nadine Adam
Researcher at Health Canada
Publications - 5
Citations - 30
Nadine Adam is an academic researcher from Health Canada. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 1, co-authored 2 publications receiving 2 citations.
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Journal ArticleDOI
Expert consultation is vital for adverse outcome pathway development: a case example of cardiovascular effects of ionizing radiation.
Vinita Chauhan,Nobuyuki Hamada,Virginie Monceau,Teni Ebrahimian,Nadine Adam,Ruth C. Wilkins,Soji Sebastian,Zarana S. Patel,Janice L. Huff,Cristoforo Simonetto,Toshiyasu Iwasaki,Jan Christian Kaiser,Sisko Salomaa,Simone Moertl,Omid Azimzadeh +14 more
TL;DR: The adverse outcome pathway (AOP) approach was used with consultation from field experts to delineate connectivities of events specifically to cardiovascular disease (CVD) initiation and progression, and the questions and discussions needed to develop an AOP for CVD resulting from ionizing radiation (IR) exposure.
Journal ArticleDOI
Deploying elements of scoping review methods for adverse outcome pathway development: a space travel case example
Tatiana Kozbenko,Nadine Adam,Vita Lai,Snehpal Sandhu,Jacqueline Kuan,Danicia Flores,Meghan Appleby,Hanna Parker,Robyn Hocking,Katya Tsaioun,Carole L. Yauk,Ruth C. Wilkins,Vinita Chauhan +12 more
TL;DR: A protocol for AOP weight of evidence gathering that harnesses elements of both scoping review methods and artificial intelligence tools to increase transparency while reducing bias and workload of human screeners is created.
Journal ArticleDOI
Meta-analysis of transcriptomic datasets using benchmark dose modeling shows value in supporting radiation risk assessment
Vinita Chauhan,Nadine Adam,Byron Kuo,Andrew Williams,Carole L. Yauk,Ruth C. Wilkins,Robert Stainforth +6 more
TL;DR: Analysis of datasets with relatively similar dose-ranges under comparable experimental conditions showed a bi-modal distribution with a high degree of consistency in BMD values across shared genes and pathways, particularly for those below the 25th percentile of total distribution by dose.
Journal ArticleDOI
Evaluating the influences of confounding variables on benchmark dose using a case study in the field of ionizing radiation
Nadine Adam,Ngoc Q. Vuong,Hailey Adams,Byron Kuo,Afshin Beheshti,Carole L. Yauk,Ruth C. Wilkins,Vinita Chauhan +7 more
TL;DR: Although further validation of the data is needed, these initial findings suggest BMD values for radiation relevant genes and pathways are robust and could be explored further in future studies.
Journal ArticleDOI
Benchmark dose modeling of transcriptional data: a systematic approach to identify best practices for study designs used in radiation research
R. M. Stainforth,Ngoc Q. Vuong,Nadine Adam,Byron Kuo,Ruth C. Wilkins,Carole L. Yauk,Afshin Beheshti,Vinita Chauhan +7 more
TL;DR: Successful application of transcriptomic BMD modeling for radiation datasets requires considerations of the exposure dose and the number of biological replicates.