N
Nadine Francotte
Publications - 4
Citations - 224
Nadine Francotte is an academic researcher. The author has contributed to research in topics: Single-nucleotide polymorphism & Neuroblastoma. The author has an hindex of 3, co-authored 4 publications receiving 220 citations.
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Journal ArticleDOI
Quantification of MYCN, DDX1, and NAG Gene Copy Number in Neuroblastoma Using a Real-Time Quantitative PCR Assay
Katleen De Preter,Frank Speleman,Valérie Combaret,John Lunec,Genevieve Laureys,Bert H.J. Eussen,Nadine Francotte,Julian Board,Andrew D.J. Pearson,Anne De Paepe,Nadine Van Roy,Jo Vandesompele +11 more
TL;DR: A real-time quantitative PCR assay is developed and evaluated as an alternative for time-consuming Southern blot analysis (SB), and as a second independent technique in parallel with fluorescence in situ hybridization (FISH) analysis, which pointed out that DDX1 and NAG amplification has no additional adverse effect on prognosis.
Journal ArticleDOI
Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics
Jo Vandesompele,Evi Michels,Katleen De Preter,Björn Menten,Alexander Schramm,Angelika Eggert,Peter F. Ambros,Valérie Combaret,Nadine Francotte,Francesca Antonacci,Anne De Paepe,Genevieve Laureys,Franki Speleman,Nadine Van Roy +13 more
TL;DR: Application of chromosome 17 tiling path BAC arrays on a panel of 69 primary tumors and 28 NB cell lines to reduce the current smallest region of gain and facilitate identification of candidate dosage sensitive genes showed that dosage sensitive NB oncogenes are most likely located in the gained region immediately distal to the most distal breakpoint of the 2 breakpoint regions.
Journal ArticleDOI
CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients.
Ali Rihani,Bram De Wilde,Fjoralba Zeka,Genevieve Laureys,Nadine Francotte,Gian Paolo Tonini,Simona Coco,Rogier Versteeg,Rosa Noguera,Johannes H. Schulte,Angelika Eggert,Raymond L. Stallings,Franki Speleman,Jo Vandesompele,Tom Van Maerken +14 more
TL;DR: In this paper, the impact of 21 SNPs on overall survival, event-free survival, age at diagnosis, myCN status, and stage of the disease in 500 neuroblastoma patients was investigated.
CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients
Ali Rihani,Bram De Wilde,Fjoralba Zeka,Genevieve Laureys,Nadine Francotte,Gian Paolo Tonini,Simona Coco,Rogier Versteeg,Rosa Noguera,Johannes H. Schulte,Angelika Eggert,Raymond L. Stallings,Franki Speleman,Jo Vandesompele,Tom Van Maerken +14 more
TL;DR: A missense SNP in exon 10 of the CASP8 gene SNP D302H was associated with worse overall and event-free survival in patients with MYCN-amplified neuroblastoma tumors.