Showing papers in "Modern Pathology in 2002"

TL;DR: D2-40 stained all cases of cutaneous KS at all stages of progression, supporting the concept that this disease originates from a cell type capable of undergoing lymphatic differentiation and is valuable for studying benign and malignant vascular disorders in routinely processed tissue specimens.

TL;DR: It is demonstrated that in addition to IMT, abnormalities of ALK1 and p80 expression with a variety of structural chromosomal changes are found in several sarcomas, especially rhabdomyosarcoma and malignant peripheral nerve sheath tumor.

TL;DR: The results here support a dichotomy in the dysplasia–CIS sequence in the pancreas and support the previous impression that MUC2 (the mucin associated with gel formation) is a marker of the “indolent” pathway (intraductal papillary mucinous neoplasm and colloid carcinoma).

TL;DR: Histologic identification of myxofibrous lesions of the jaws (odontogenic myxoma, odontogenic fibroma, desmoplastic fibroma) is necessary to avoid the diagnostic pitfall of overdiagnosis of similar-appearing follicular sacs and dental pulps.

TL;DR: The study confirms the diagnostic utility of CK 5/6 immunohistochemistry in distinguishing biphasic mesothelioma from pulmonary adenocarcinoma but raises caution about its use for the differential diagnosis of pleural or peritoneal malignant mesotelioma versus pleural/peritoneal metastatic nonpulmonary adenOCarcinomas.

TL;DR: This article reviews and updates the understanding of neuroectodermal neoplasms arising in the head and neck and recommends subclassifications of well-differentiated, moderately differentiated, and poorly differentiated neuroendocrine carcinoma.

TL;DR: Results show that RNA can be reliably isolated from formalin-fixed, paraffin-embedded tissue sections and can produce reliable quantitative RT-PCR data, however, results for some markers are adversely affected by prolonged formalin fixation times.

TL;DR: A real-time quantitative PCR assay is developed and evaluated as an alternative for time-consuming Southern blot analysis (SB), and as a second independent technique in parallel with fluorescence in situ hybridization (FISH) analysis, which pointed out that DDX1 and NAG amplification has no additional adverse effect on prognosis.

TL;DR: The results suggest that women appear to have a better prognosis than men in advanced gastric carcinoma, and gender differences in some host defense mechanisms and particularly in neutrophil function may be responsible for this event.

TL;DR: In summary, LEC of the pancreas is a rare but distinctive lesion that may be seen in the tail of the organ where most cystic pancreatic neoplasms are encountered and should be considered in the clinical differential diagnosis of mucinous cystic neoplasm that affect a similar age group.

TL;DR: The cytologic features and biomarker expression profile of PL/DLCIS are similar to those of PLCIS with invasion but somewhat different from those of classic LCIS and ductal carcinoma in situ.

TL;DR: By permitting observation of morphology using a bright-field microscope, CISH is an accurate, practical, and economical approach to screen HER2 status in breast cancers and is a useful methodology for confirming ambiguous IHC results.

TL;DR: The findings from this study suggest that the genetic event of HER2/neu gene amplification/protein overexpression may not play a key role in the progression of ductal carcinoma in situ to invasive carcinoma and that other molecular alterations may be more important in the initiation of invasion in ductAL carcinoma of the breast.

TL;DR: The study and the review of the literature showed adenomas and carcinoid tumors of the middle ear to be essentially indistinguishable benign tumors.

TL;DR: Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck continue to be a source of confusion for both the clinician and pathologist.

TL;DR: The data suggest the presence of a unique tumor entity within tumors of probable collecting duct origin: tubular-mucinous renal tumors of low malignant potential, distinct from all previously classified renal neoplasms.

TL;DR: Multiple-tumor tissue microarrays are an efficient method for assessing the sensitivity and specificity of staining with any antibody used diagnostically and show the potential for panels of immunohistochemical stains to identify the primary site of metastatic carcinomas but also confirm the limitations of currently available antibodies in giving unequivocal tissue-specific staining patterns.

TL;DR: D deregulation of c-MYC protein is common in pancreatic cancer and that it may be involved in early neoplastic development and progression rather than in locoregional spread of invasive cancer.

TL;DR: CD10 immunohistochemically on paraffin sections of both normal and pathological breast tissues is demonstrated, comparing its staining patterns to those of smooth muscle actin (SMA), which was useful in differentiating myoepithelial cells from thin vascular wall in intracystic lesions with delicate papillae.

TL;DR: The finding of different patterns of c-kit expression in tubular and solid variants of ACC supports the concept of solid variant ACC as a high-grade tumor, with progression toward an entirely “inner cell” phenotype.

TL;DR: MSI+ phenotype in gastric cancers was found to have distinct clinicopathologic characteristics and to be predictive of a favorable outcome in advanced carcinoma.

TL;DR: Use of TP for consultation in CUC-associated dysplasia has a moderate level of interobserver agreement, and diagnoses rendered by evaluation of digitalized images tended to be of a lower grade than that observed after a review of the glass slides.

TL;DR: Except in a certain subset of cases, aneusomy 17 probably is not a significant factor for HER-2/neu protein expression or for clinical assessment of HER- 2/neU status.

TL;DR: Examination of breast tissues from surgical specimens from 73 premenopausal women and use morphological criteria to characterize the stage of the menstrual cycle will permit retrospective analysis of large archival databases to analyze the effect of timing of surgery in relation to menstrual cycle phase.

TL;DR: Thymic B cells are supported as the putative normal counterpart of primary mediastinal large B-cell lymphomas and MAL is identified as a distinct molecular marker of this lymphoma subtype among diffuseLarge B- cell lymphomas.

TL;DR: The results suggest that thyroid transcription factor-1 can play an important role for the maintenance and/or differentiation process in bronchiolar and alveolar cells.

TL;DR: It is acknowledged now that there is no increased risk of a second primary breast cancer in women who have had previous salivary gland cancer, but there is some increased risk for the development of second primary cancers of the oropharynx, thyroid gland and lung.

TL;DR: Three cases of extranodal FDC sarcoma in the tonsil and pharynx reported in the recent literature were initially misdiagnosed, and this tumor has numerous distinctive histological features that should bring the neoplasm into the differential diagnosis.

TL;DR: In the Veterans Administration hospital setting, the clinical stage and the expressions of p53 and Her2-neu in male breast carcinoma may be prognostically useful markers in guiding future treatment in prospective studies, whereas ER, PR, and MiB1 expressions are of limited value.

TL;DR: This study emphasizes the use of FISH analysis for the direct detection of t(11;14) because its applicability and sensitivity largely exceeded those of other techniques and may provide some informations on secondary cytogenetic changes of potential clinical relevance.