N
Nagahiro Saijo
Researcher at AstraZeneca
Publications - 386
Citations - 31129
Nagahiro Saijo is an academic researcher from AstraZeneca. The author has contributed to research in topics: Lung cancer & Chemotherapy. The author has an hindex of 65, co-authored 386 publications receiving 28187 citations. Previous affiliations of Nagahiro Saijo include Harvard University.
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Journal ArticleDOI
Efficacy and Safety of Pemetrexed in Combination with Cisplatin for Malignant Pleural Mesothelioma: A Phase I/II Study in Japanese Patients
Kazuhiko Nakagawa,Koichi Yamazaki,Hideo Kunitoh,Toyoaki Hida,Kenichi Gemba,Tetsu Shinkai,Yukito Ichinose,S. Adachi,Yoshihiro Nambu,Nagahiro Saijo,Masahiro Fukuoka +10 more
TL;DR: The Pem/Cis combination provides promising activity and an acceptable safety profile for chemonaive Japanese MPM patients with the same recommend dosage and schedule used in rest of the world.
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Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients.
Kimie Sai,Yoshiro Saito,Hiromi Fukushima-Uesaka,Koichi Kurose,Nahoko Kaniwa,Naoyuki Kamatani,Kuniaki Shirao,Noboru Yamamoto,Tetsuya Hamaguchi,Hideo Kunitoh,Yuichiro Ohe,Tomohide Tamura,Yasuhide Yamada,Hironobu Minami,Atsushi Ohtsu,Teruhiko Yoshida,Nagahiro Saijo,Jun-ichi Sawada +17 more
TL;DR: It is suggested that CYP3A4*16B was associated with decreased metabolism of irinotecan to APC, however, the clinical impact of CYP2A4 genotypes on total clearance and irinOTecan toxicities was not significant.
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Glutathione Homeostasis in Human Hepatic Cells: Overexpression of γ-Glutamylcysteine Synthetase Gene in Cell Lines Resistant to Buthionine Sulfoximine, an Inhibitor of Glutathione Synthesis
Toshiya Tanaka,Takeshi Uchiumi,Kimitoshi Kohno,Akira Tomonari,Kazuto Nishio,Nagahiro Saijo,Takahito Kondo,Michihiko Kuwano +7 more
TL;DR: In this article, the expression of a dominant-negative mutant of c-Jun was found to inhibit the AP1-dependent GCSh promoter activity in BSO-resistant hepatic cells.
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Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).
Su Ryang Kim,Takahiro Nakamura,Yoshiro Saito,Kimie Sai,Toshiharu Nakajima,Hirohisa Saito,Kuniaki Shirao,Hironobu Minami,Atsushi Ohtsu,Teruhiko Yoshida,Nagahiro Saijo,Shogo Ozawa,Jun-ichi Sawada +12 more
TL;DR: Twelve novel single nucleotide polymorphisms (SNPs) were found in the CES2 gene from 153 Japanese individuals, who were administered irinotecan or steroidal drugs, and among these SNPs, MPJ6_CS2005 (100C>T) resulted in an amino acid alteration.
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Control of cisplatin-induced delayed emesis with metoclopramide and dexamethasone: a randomized controlled trial.
Tetsu Shinkai,Nagahiro Saijo,Kenji Eguchi,Yasutsuna Sasaki,Tomohide Tamura,Yasuhiro Fujiwara,Masahiro Mae,Masaaki Fukuda,Yuichiro Ohe,Satoru Sasaki,Kazuhiko Nakagawa,Koichi Minato,Weon-Seon Hong,Keiichi Suemasu +13 more
TL;DR: The results of the study showed no statistically significant advantage with the combination of i.v. metoclopramide and dexamethasone for patients treated with cisplatin, in view of the short duration of anorexia and the marginal reduction in nausea.