Y
Yasuhiro Fujiwara
Researcher at University of Tokyo
Publications - 396
Citations - 7430
Yasuhiro Fujiwara is an academic researcher from University of Tokyo. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 43, co-authored 384 publications receiving 6128 citations. Previous affiliations of Yasuhiro Fujiwara include Okayama University & Pharmaceuticals and Medical Devices Agency.
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Journal ArticleDOI
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Toshihiko Doi,Kohei Shitara,Yoichi Naito,Akihiko Shimomura,Yasuhiro Fujiwara,Kan Yonemori,Chikako Shimizu,Tatsunori Shimoi,Yasutoshi Kuboki,Nobuaki Matsubara,Atsuko Kitano,Takahiro Jikoh,Caleb Lee,Yoshihiko Fujisaki,Yusuke Ogitani,Antoine Yver,Kenji Tamura +16 more
TL;DR: In this small, heavily pretreated study population, trastuzumab deruxtecan showed antitumour activity, even in low HER2-expressing tumours, and the most likely recommended phase 2 dosing is 5·4 or 6·4 mg/kg.
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Novel combination of serum microRNA for detecting breast cancer in the early stage
Akihiko Shimomura,Sho Shiino,Junpei Kawauchi,Satoko Takizawa,Hiromi Sakamoto,Juntaro Matsuzaki,Makiko Ono,Fumitaka Takeshita,Shumpei Niida,Chikako Shimizu,Yasuhiro Fujiwara,Takayuki Kinoshita,Kenji Tamura,Takahiro Ochiya +13 more
TL;DR: A combination of five miRNA was found to be able to detect breast cancer, and this combination had a sensitivity of 97.3%, specificity of 82.9% and accuracy of 89.7% in the test cohort.
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Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer
Makiko Ono,Hitoshi Tsuda,Chikako Shimizu,Sohei Yamamoto,Tatsuhiro Shibata,Harukaze Yamamoto,Taizo Hirata,Kan Yonemori,Masashi Ando,Kenji Tamura,Noriyuki Katsumata,Takayuki Kinoshita,Yuichi Takiguchi,Hideki Tanzawa,Yasuhiro Fujiwara +14 more
TL;DR: The degree of TIL correlated with immune response appear to play a substantial role in the response to NAC in TNBC, and Expression of basal markers and p53, histological grade 3, high TIL scores, and apoptosis were more frequent in T NBC and the HR−/her2+ subtype than in the HR+/HER2− subtype.
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64Cu-DOTA-Trastuzumab PET Imaging in Patients with HER2-Positive Breast Cancer
Kenji Tamura,Hiroaki Kurihara,Kan Yonemori,Hitoshi Tsuda,Junko Suzuki,Yuzuru Kono,Natsuki Honda,Makoto Kodaira,Harukaze Yamamoto,Mayu Yunokawa,Chikako Shimizu,Koki Hasegawa,Yousuke Kanayama,Satoshi Nozaki,Takayuki Kinoshita,Yasuhiro Wada,Shusaku Tazawa,Kazuhiro Takahashi,Yasuyoshi Watanabe,Yasuhiro Fujiwara +19 more
TL;DR: 64Cu-DOTA-trastuzumab PET is feasible for the identification of HER2-positive lesions in patients with primary and metastatic breast cancer and the dosimetry and pharmacologic safety results were acceptable at the dose required for adequate PET imaging.
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Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study
Kuniko Sunami,Hitoshi Ichikawa,Takashi Kubo,Mamoru Kato,Yutaka Fujiwara,Akihiko Shimomura,Takafumi Koyama,Hiroki Kakishima,Mayuko Kitami,Hiromichi Matsushita,Eisaku Furukawa,Daichi Narushima,Momoko Nagai,Hirokazu Taniguchi,Noriko Motoi,Shigeki Sekine,Akiko Miyagi Maeshima,Taisuke Mori,Reiko Watanabe,Masayuki Yoshida,Akihiko Yoshida,Hiroshi Yoshida,Kaishi Satomi,Aoi Sukeda,Taiki Hashimoto,Toshio Shimizu,Satoru Iwasa,Kan Yonemori,Ken Kato,Chigusa Morizane,Chitose Ogawa,Noriko Tanabe,Kokichi Sugano,Nobuyoshi Hiraoka,Kenji Tamura,Teruhiko Yoshida,Yasuhiro Fujiwara,Atsushi Ochiai,Noboru Yamamoto,Takashi Kohno +39 more
TL;DR: Results indicate the utility of tumor‐profiling multiplex gene panel testing in a clinical setting in Japan and investigate the feasibility and utility of NGS‐based analysis of 114 cancer‐associated genes (the NCC Oncopanel test).