N
Nagalingeswaran Kumarasamy
Researcher at University of North Carolina at Chapel Hill
Publications - 28
Citations - 7365
Nagalingeswaran Kumarasamy is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 5, co-authored 5 publications receiving 6620 citations.
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Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Leslie Cottle,Xinyi C. Zhang,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Sharlaa Faesen,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Sarah E. Hudelson,Andrew D. Redd,Thomas R. Fleming +35 more
TL;DR: The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.
Journal ArticleDOI
Analysis of Genetic Linkage of HIV From Couples Enrolled in the HIV Prevention Trials Network 052 Trial
Susan H. Eshleman,Sarah E. Hudelson,Andrew D. Redd,Lei Wang,R. Debes,Ying Q. Chen,Craig Martens,Stacy M. Ricklefs,Ethan J. Selig,Stephen F. Porcella,Supriya Munshaw,Stuart C. Ray,Estelle Piwowar-Manning,Marybeth McCauley,Mina C. Hosseinipour,Johnstone Kumwenda,James Hakim,Suwat Chariyalertsak,Guy de Bruyn,Beatriz Grinsztejn,Nagalingeswaran Kumarasamy,Joseph Makhema,Kenneth H. Mayer,José Henrique Pilotto,Breno Santos,Thomas C. Quinn,Thomas C. Quinn,Myron S. Cohen,James P. Hughes,James P. Hughes +29 more
TL;DR: The association of early ART and reduced HIV transmission was stronger when the analysis included only linked events, and underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prevention studies involving serodiscordant couples.
Journal ArticleDOI
The WHO Global Tuberculosis 2021 Report – not so good news and turning the tide back to End TB
Chakaya Jeremiah,Eskild Petersen,Rebecca Nantanda,Brenda Mungai,Giovanni Battista Migliori,Farhana Amanullah,Patrick Lungu,Francine Ntoumi,Nagalingeswaran Kumarasamy,Markus Maeurer,Alimuddin Zumla +10 more
TL;DR: The authors in this paper reviewed the data presented in the global TB report and discussed the current constraints in global response and emphasized that ending the TB epidemic will require bold leadership, optimization of existing interventions, widespread coverage, addressing social determinants of TB and importantly mobilization of adequate funding required for TB care and prevention.
Journal ArticleDOI
Undisclosed Antiretroviral Drug Use in a Multinational Clinical Trial (HIV Prevention Trials Network 052)
Jessica M. Fogel,Lei Wang,Teresa L. Parsons,San San Ou,Estelle Piwowar-Manning,Ying Q. Chen,Victor Mudhune,Mina C. Hosseinipour,Johnstone Kumwenda,James Hakim,Suwat Chariyalertsak,Ravindre Panchia,Ian Sanne,Nagalingeswaran Kumarasamy,Beatriz Grinsztejn,Joseph Makhema,José Henrique Pilotto,Breno Santos,Kenneth H. Mayer,Marybeth McCauley,Theresa Gamble,Namandjé N. Bumpus,Craig W. Hendrix,Myron S. Cohen,Susan H. Eshleman +24 more
TL;DR: ARS drugs were detected in follow-up samples from participants who were not receiving study-administered treatment and may be useful in addition to self-report of ARV drug use in some clinical trial settings.