N
Nan Hyung Hong
Researcher at Vanderbilt University
Publications - 10
Citations - 1302
Nan Hyung Hong is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Endosome & Cortactin. The author has an hindex of 9, co-authored 10 publications receiving 1092 citations. Previous affiliations of Nan Hyung Hong include Centers for Disease Control and Prevention & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke.
Soon-Tae Lee,Kon Chu,Kunhwa Jung,Se Jeong Kim,Dong Hyun Kim,Kyung Mook Kang,Nan Hyung Hong,Jin Hee Kim,Jae Joon Ban,Hee-Kwon Park,Seung U. Kim,Chung Gyu Park,Sang Kun Lee,Manho Kim,Jae Kyu Roh +14 more
TL;DR: Early intravenous NSC injection displayed anti-inflammatory functionality that promoted neuroprotection, mainly by interrupting splenic inflammatory responses after ICH.
Journal ArticleDOI
KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes
Andrew J. McKenzie,Daisuke Hoshino,Nan Hyung Hong,Diana J. Cha,Jeffrey L. Franklin,Robert J. Coffey,Robert J. Coffey,Robert J. Coffey,James G. Patton,Alissa M. Weaver,Alissa M. Weaver +10 more
TL;DR: This work uses isogenic colon cancer cell lines to show that overactivity of KRAS due to mutation inhibits localization of Ago2 to multivesicular endosomes (MVEs) and decreases Ago2 secretion in exosomes, and identifies a key regulatory signaling event that controls Ago 2 secretion inExosomes.
Journal ArticleDOI
Cortactin promotes exosome secretion by controlling branched actin dynamics.
Seema Sinha,Daisuke Hoshino,Nan Hyung Hong,Kellye C. Kirkbride,Nathan E. Grega-Larson,Motoharu Seiki,Matthew J. Tyska,Alissa M. Weaver,Alissa M. Weaver +8 more
TL;DR: It is shown that the cytoskeletal and tumor-overexpressed protein cortactin promotes secretion of exosomes from cancer cells by stabilizing dynamic cortical actin docking sites for multivesicular endosomes, suggesting a potential mechanism by which Cortactin may promote tumor aggressiveness.
Journal ArticleDOI
Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model.
Jeong Min Kim,Soon-Tae Lee,Soon-Tae Lee,Kon Chu,Kon Chu,Keun-Hwa Jung,Keun-Hwa Jung,Keun-Hwa Jung,Eun-Cheol Song,Eun-Cheol Song,Eun-Cheol Song,Se Jeong Kim,Dong In Sinn,Dong In Sinn,Jin Hee Kim,Dong-Kyu Park,Kyung-Mook Kang,Nan Hyung Hong,Hee-Kwon Park,Chong-Hyun Won,Chong-Hyun Won,Kyu Han Kim,Manho Kim,Manho Kim,Sang Kun Lee,Sang Kun Lee,Jae-Kyu Roh,Jae-Kyu Roh +27 more
TL;DR: In summary, ASCs transplantation in the ICH model reduced both acute cerebral inflammation and chronic brain degeneration, and promoted long-term functional recovery.
Journal ArticleDOI
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin–actin interactions
TL;DR: The late endosomal lipid PI(3,5)P2 binds to cortactin through the filamentous actin (F-actin) binding domain of Cortactin, leading to removal of cortactIn from endosome actin networks and inhibition of cortACTin-mediated branched actin nucleation and stabilization.