Nansha Gao

TL;DR: In vitro and in vivo antitumors experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo‐, gene‐, and photothermal treatments in one system.

TL;DR: Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy.

TL;DR: Wang et al. as mentioned in this paper developed a kind of mannose-doping doxorubicin-loading mesoporous silica nanoparticle (MSN-Man-DOX) and coated by polydopamine-Gd3+ (PDAGd) metal-phenolic networks, as well as modified by poly (2-Ethyl-2-Oxazoline) (PEOz), constructing a novel nanomedicine MSN-ManDOX@PDAGd-PEOZ, which had outstanding tumor enrichment and penetration abilities

TL;DR: In this review, the latest surface modification strategies for the penetration of nanomedicine into solid tumors are summarized and classified into “bulldozer strategies” and “mouse strategies.”

TL;DR: Both in vitro and in vivo experiments proved that the synergistic therapy combining chemotherapy with photothermal therapy had high biocompatibility, outstanding antitumor efficacy and potential clinical application.