Journal ArticleDOI
TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance.
Wei Cheng,Chaoyu Liang,Lv Xu,Gan Liu,Gan Liu,Nansha Gao,Wei Tao,Lingyan Luo,Yixiong Zuo,Xusheng Wang,Xudong Zhang,Xiaowei Zeng,Lin Mei,Lin Mei +13 more
TLDR
Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy.Abstract:
A nanocarrier system of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug-resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR). The normal A549 cells and drug-resistant A549 cells are employed to access the cytotoxicity and cellular uptake of the NPs. The therapeutic effects of TPGS-conjugated nanoparticles are evaluated in vitro and in vivo. Compared with free DOX and DOX-loaded NPs without TPGS ligand modification, MSNs-DOX@PDA-TPGS exhibits outstanding capacity to overcome multidrug resistance and shows better in vivo therapeutic efficacy. This splendid drug delivery platform can also be sued to deliver other hydrophilic and hydrophobic drugs.read more
Citations
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Journal ArticleDOI
Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine
TL;DR: In this review, recent significant research developments of PDA including its synthesis and polymerization mechanism, physicochemical properties, different nano/micro-structures and diverse applications are summarized and discussed.
Journal ArticleDOI
Recent progress in drug delivery
Chong Li,Jiancheng Wang,Yiguang Wang,Huile Gao,Gang Wei,Yongzhuo Huang,Haijun Yu,Yong Gan,Yongjun Wang,Lin Mei,Huabing Chen,Haiyan Hu,Zhiping Zhang,Yiguang Jin +13 more
TL;DR: This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples.
Journal ArticleDOI
Recent Advances in the Application of Vitamin E TPGS for Drug Delivery.
TL;DR: The recent advances of TPGS in drug delivery including T PGS based prodrugs, nitric oxide donor and polymers, and unmodified TPGs based formulations are discussed, focused on enhancing delivery efficiency as well as the therapeutic effect of agents.
Journal ArticleDOI
A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy
Wei Cheng,Junpeng Nie,Nansha Gao,Gan Liu,Wei Tao,Xiaojun Xiao,Lijuan Jiang,Zhigang Liu,Xiaowei Zeng,Lin Mei +9 more
TL;DR: In vitro and in vivo antitumors experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo‐, gene‐, and photothermal treatments in one system.
Journal ArticleDOI
Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling
Hamed Amani,Rouhollah Habibey,Fereshteh Shokri,Seyed Javad Hajmiresmail,Omid Akhavan,Alireza Mashaghi,Hamidreza Pazoki-Toroudi +6 more
TL;DR: It is demonstrated that administration of the biodegradable nanoparticles leads to resolution of brain edema, protection of axons in hippocampus region, and myelination of hippocampal area after cerebral ischemic stroke in a murine model.
References
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Journal ArticleDOI
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
TL;DR: This review highlights the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers and envision that these MSN-based systems have a great potential for a variety of drug delivery applications.
Journal ArticleDOI
A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules.
Cheng-Yu Lai,Brian G. Trewyn,Dusan M. Jeftinija,Ksenija Jeftinija,Shu Xu,Srdija Jeftinija,Victor S.-Y. Lin +6 more
TL;DR: An MCM-41 type mesoporous silica nanosphere-based controlled-release delivery system has been synthesized and characterized using surface-derivatized cadmium sulfide nanocrystals as chemically removable caps to encapsulate several pharmaceutical drug molecules and neurotransmitters inside the organically functionalized MSN Mesoporous framework.
Journal ArticleDOI
Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs.
Khin Yin Win,Si-Shen Feng +1 more
TL;DR: It is highly feasible for nanoparticles of biodegradable polymers to be applied to promote oral chemotherapy by using Caco-2 cells, showing that surface modification of PLGA nanoparticles with vitamin E TPGS notably improved the cellular uptake.
Journal ArticleDOI
Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings
TL;DR: A facile two-step aqueous approach to immobilization of biomolecules onto surfaces is reported, which exploits the latent reactivity of the biomimetic polymer thin film towards nucleophiles, is unaffected by water, and allows for discrimination betweenucleophiles on the basis of pKa.
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A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS.
L Mu,Si-Shen Feng +1 more
TL;DR: Vitamin E TPGS has great advantages for the manufacture of polymeric nanoparticles for controlled release of paclitaxel and other anti-cancer drugs and could be a novel surfactant as a matrix material when blended with other biodegradable polymers.