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Naoki Tomita
Researcher at Tohoku University
Publications - 70
Citations - 3293
Naoki Tomita is an academic researcher from Tohoku University. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 28, co-authored 64 publications receiving 2786 citations.
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Journal ArticleDOI
A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.
Koh Iwasaki,Takuma Satoh-Nakagawa,Masahiro Maruyama,Yasutake Monma,Miyako Nemoto,Naoki Tomita,Haruko Tanji,Hironori Fujiwara,Takashi Seki,Masahiko Fujii,Hiroyuki Arai,Hidetada Sasaki +11 more
TL;DR: The traditional Chinese herbal medicine Yi-Gan San improves BPSD and ADL and follow-up studies using a double-blinded, placebo-controlled design are recommended.
Journal ArticleDOI
18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.
Ryuichi Harada,Nobuyuki Okamura,Shozo Furumoto,Katsutoshi Furukawa,Aiko Ishiki,Naoki Tomita,Tetsuro Tago,Kotaro Hiraoka,Shoichi Watanuki,Miho Shidahara,Masayasu Miyake,Yoichi Ishikawa,Rin Matsuda,Akie Inami,Takeo Yoshikawa,Yoshihito Funaki,Ren Iwata,Manabu Tashiro,Kazuhiko Yanai,Hiroyuki Arai,Yukitsuka Kudo +20 more
TL;DR: A novel tau PET tracer is developed through compound optimization of arylquinoline derivatives that bound to neurofibrillary tangles selectively and with a higher signal-to-background ratio than did THK5117 in Alzheimer disease patients.
Journal ArticleDOI
Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression.
Takashi Ohrui,Naoki Tomita,T. Sato-Nakagawa,Toshifumi Matsui,Masahiro Maruyama,K. Niwa,Hiroyuki Arai,Hidetada Sasaki +7 more
TL;DR: The hypothesis that treatment with brain-penetrating ACE inhibitors would slow the rate of cognitive decline in mild-to-moderate AD patients with hypertension is tested.
Journal ArticleDOI
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
Akinori Miyashita,Asako Koike,Gyungah Jun,Li-San Wang,Satoshi Takahashi,Etsuro Matsubara,Takeshi Kawarabayashi,Mikio Shoji,Naoki Tomita,Hiroyuki Arai,Takashi Asada,Yasuo Harigaya,Masaki Ikeda,Masakuni Amari,Haruo Hanyu,Susumu Higuchi,Takeshi Ikeuchi,Masatoyo Nishizawa,Masaichi Suga,Yasuhiro Kawase,Hiroyasu Akatsu,Kenji Kosaka,Takayuki Yamamoto,Masaki Imagawa,Tsuyoshi Hamaguchi,Masahito Yamada,Takashi Moriaha,Masatoshi Takeda,Takeo Takao,Kenji Nakata,Yoshikatsu Fujisawa,Ken Sasaki,Ken Watanabe,Kenji Nakashima,Katsuya Urakami,Terumi Ooya,Mitsuo Takahashi,Takefumi Yuzuriha,Kayoko Serikawa,Seishi Yoshimoto,Ryuji Nakagawa,Jong-Won Kim,Chang-Seok Ki,Hong-Hee Won,Duk L. Na,Sang Won Seo,Inhee Mook-Jung,Peter St George-Hyslop,Richard Mayeux,Jonathan L. Haines,Margaret A. Pericak-Vance,Makiko Yoshida,Nao Nishida,Katsushi Tokunaga,Ken Yamamoto,Shoji Tsuji,Ichiro Kanazawa,Yasuo Ihara,Gerard D. Schellenberg,Lindsay A. Farrer,Ryozo Kuwano +60 more
TL;DR: Genome-wide significance of LOAD with SORL1 is demonstrated for the first time and the role of other known loci for LOAD in Japanese is confirmed and highlights the importance of examining associations in multiple ethnic populations.
Journal ArticleDOI
Randomized Phase II Trial Comparing Nitroglycerin Plus Vinorelbine and Cisplatin With Vinorelbine and Cisplatin Alone in Previously Untreated Stage IIIB/IV Non–Small-Cell Lung Cancer
Hiroyasu Yasuda,Mutsuo Yamaya,Katsutoshi Nakayama,Takahiko Sasaki,Satoru Ebihara,Akio Kanda,Masanori Asada,Daisuke Inoue,Tomoko Suzuki,Tatsuma Okazaki,Hidenori Takahashi,Motoki Yoshida,Tomohiro Kaneta,Kota Ishizawa,Shinsuke Yamanda,Naoki Tomita,Miyako Yamasaki,Akiko Kikuchi,Hiroshi Kubo,Hidetada Sasaki +19 more
TL;DR: Use of nitroglycerin combined with vinorelbine and cisplatin may improve overall response and TTP in patients with stage IIIB/IV NSCLC.