N
Naoto Hirano
Researcher at University of Tokyo
Publications - 36
Citations - 2767
Naoto Hirano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 20, co-authored 29 publications receiving 2694 citations. Previous affiliations of Naoto Hirano include Harvard University.
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Journal ArticleDOI
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.
Ryuichi Sakai,Akihiro Iwamatsu,Naoto Hirano,Seishi Ogawa,Tomoyuki Tanaka,Hiroyuki Mano,Yoshio Yazaki,H Hirai +7 more
TL;DR: The p130 (designated Cas for Crk‐associated substrate) is a common cellular target of phosphorylation signal via v‐Crk and v‐Src oncoproteins, and its unique structure indicates the possible role of p130Cas in assembling signals from multiple SH2‐containing molecules.
Journal ArticleDOI
Transplantation of anergic histoincompatible bone marrow allografts.
Eva C. Guinan,Vassiliki A. Boussiotis,Donna Neuberg,Lisa L. Brennan,Naoto Hirano,Lee M. Nadler,John G. Gribben +6 more
TL;DR: Donor bone marrow treated ex vivo to induce anergy to alloantigens from the recipient can reconstitute hematopoiesis in vivo with a relatively low risk of GVHD.
Journal ArticleDOI
Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells
Dimitrios Tzachanis,Gordon J. Freeman,Naoto Hirano,Andre A. F. L. van Puijenbroek,Michael W. Delfs,Alla Berezovskaya,Lee M. Nadler,Vassiliki A. Boussiotis +7 more
TL;DR: T cell quiescence is an actively maintained phenotype that must be suppressed for T cell activation to occur and Tob, a member of an anti-proliferative gene family, was highly expressed in anergic T cell clones.
Journal ArticleDOI
Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application.
Michael von Bergwelt-Baildon,Robert H. Vonderheide,Britta Maecker,Naoto Hirano,Karen S. Anderson,Marcus O. Butler,Zhinan Xia,Wan Y. Zeng,Kai W. Wucherpfennig,Lee M. Nadler,Joachim L. Schultze,Joachim L. Schultze +11 more
TL;DR: This work demonstrates that CD40-B cells from healthy donors and cancer patients are fully functional and equally expanded in long-term cultures, and are an excellent source of professional APCs for immune assessment, antigen discovery, and antigen-specific immunotherapy.
Journal ArticleDOI
Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias
S Ogawa,Naoto Hirano,Noriharu Sato,Tokiharu Takahashi,Akira Hangaishi,Kozo Tanaka,Mineo Kurokawa,Tomoyuki Tanaka,Kinuko Mitani,Yoshio Yazaki +9 more
TL;DR: The results suggest that loss of the CDK4I function may contribute to immortalization of human leukemia cells and play a causative role at least in development of human lymphocytic leukemias.