Y
Young-Yun Kong
Researcher at Seoul National University
Publications - 113
Citations - 17638
Young-Yun Kong is an academic researcher from Seoul National University. The author has contributed to research in topics: Notch signaling pathway & Cellular differentiation. The author has an hindex of 44, co-authored 108 publications receiving 16793 citations. Previous affiliations of Young-Yun Kong include Amgen & Ontario Institute for Cancer Research.
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Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Journal ArticleDOI
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
Young-Yun Kong,Ulrich Feige,Iidiko Sarosi,Brad Bolon,Anna Tafuri,Sean Morony,Casey Capparelli,Ji Li,Robin Elliott,Susan McCabe,Tom Wong,G Campagnuolo,Erika Moran,Earl R. Bogoch,Gwyneth Van,Linh T. Nguyen,Pamela S. Ohashi,David L. Lacey,Eleanor N. Fish,William J. Boyle,Josef M. Penninger,Josef M. Penninger +21 more
TL;DR: The results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology.
Journal ArticleDOI
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Nicholas Joza,Nicholas Joza,Santos A. Susin,Eric Daugas,William L. Stanford,Sarah K. Cho,Carol Y. J. Li,Takehiko Sasaki,Takehiko Sasaki,Andrew J. Elia,H.-Y. Mary Cheng,H.-Y. Mary Cheng,Luigi Ravagnan,Karine F. Ferri,Naoufal Zamzami,Andrew Wakeham,Razqallah Hakem,Hiroki Yoshida,Young-Yun Kong,Tak W. Mak,Juan Carlos Zúñiga-Pflücker,Guido Kroemer,Josef M. Penninger,Josef M. Penninger +23 more
TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Journal ArticleDOI
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Atsushi Hirao,Young-Yun Kong,Shuhei Matsuoka,Andrew Wakeham,Jürgen Ruland,Hiroki Yoshida,Dou Liu,Stephen J. Elledge,Tak W. Mak +8 more
TL;DR: Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding, and provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage.
Journal ArticleDOI
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.
Hiroki Yoshida,Hiroki Yoshida,Young-Yun Kong,Young-Yun Kong,Ritsuko Yoshida,Ritsuko Yoshida,Andrew J. Elia,Andrew J. Elia,Anne Hakem,Anne Hakem,Razqallah Hakem,Razqallah Hakem,Josef M. Penninger,Josef M. Penninger,Tak W. Mak,Tak W. Mak +15 more
TL;DR: Data indicate that Apaf1 plays a central role in the common events of mitochondria-dependent apoptosis in most death pathways and that this role is critical for normal development.