Natalie L. Hauglund

TL;DR: This work shows that the clinically used α2-adrenergic agonist dexmedetomidine that enhances EEG slow-wave activity, increases brain and spinal cord drug exposure of intrathecally administered drugs in mice and rats, and demonstrates that modulation of glymphatic flow has a distinct impact on the distribution of intrathletic administered therapeutics.

TL;DR: Cisterna magna cannulation can be utilized as a conduit for fast, brain-wide delivery of signaling molecules and metabolic substrates that could not otherwise cross the blood brain barrier (BBB).

TL;DR: Recent developments focusing on the glymphatic system and sleep are reviewed and future studies that could shed new light on the reasons for the necessity of sleep for brain health are suggested.

TL;DR: In this paper , the authors used fiber photometry in mice to examine how release of the arousal mediator norepinephrine (NE) shapes sleep micro-architecture, and they showed that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles.

TL;DR: This paper showed the existence of a fourth meningeal layer called the subarachnoid lymphatic-like membrane (SLYM), which is morpho and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells.