Celia Kjaerby

TL;DR: It is suggested that multiple forms of autism may alter the physiology of specific deep-layer prefrontal neurons that project to subcortical targets, and a highly overlapping population—prefrontal D2R+ neurons—plays an important role in both normal and abnormal social behavior, such that targeting these cells can elicit potentially therapeutic effects.

TL;DR: In this paper , the authors used fiber photometry in mice to examine how release of the arousal mediator norepinephrine (NE) shapes sleep micro-architecture, and they showed that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles.

TL;DR: A combination of optogenetics and synaptic physiology is used to show that serotonin acts presynaptically via 5-HT1B receptors to selectively suppress inputs from the contralateral mPFC and ventral hippocampus, while sparing those from mediodorsal thalamus.

TL;DR: The current available literature on astrocytic Ca2+ signaling in awake animals is reviewed and the development and availability of innovative new methodological tools that are opening up for new ways of visualizing and perturbingAstrocyte activity in awake behaving animals are looked at.

TL;DR: The observed impairments in GABAergic function are compatible with the alteration of GABAergic markers as well as cognitive dysfunction observed in early postnatal PCP-treated rats and support the hypothesis that PCP administration during neurodevelopment affects the functionality of interneurons in later life.