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Natalie Landon-Brace
Researcher at Brigham and Women's Hospital
Publications - 4
Citations - 123
Natalie Landon-Brace is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Tyrosine-kinase inhibitor & Cabozantinib. The author has an hindex of 2, co-authored 4 publications receiving 88 citations. Previous affiliations of Natalie Landon-Brace include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity.
Akash Patnaik,Kenneth D. Swanson,Eva Csizmadia,Aniruddh Solanki,Aniruddh Solanki,Natalie Landon-Brace,Natalie Landon-Brace,Marina P. Gehring,Marina P. Gehring,Katja Helenius,Brian Olson,Athalia Rachel Pyzer,Lily C. Wang,Olivier Elemento,Jesse Novak,Thomas B. Thornley,John M. Asara,Laleh Montaser,Joshua J. Timmons,Todd M. Morgan,Yugang Wang,Elena Levantini,Elena Levantini,Elena Levantini,John G. Clohessy,Kathleen Kelly,Pier Paolo Pandolfi,Jacalyn Rosenblatt,David Avigan,Huihui Ye,Jeffrey M. Karp,Jeffrey M. Karp,Sabina Signoretti,Steven P. Balk,Lewis C. Cantley +34 more
TL;DR: This study is the first to demonstrate that a tyrosine kinase inhibitor can activate neutrophil-mediated antitumor innate immunity, resulting in invasive cancer clearance, in mice.
Journal ArticleDOI
A resistance-sensing mechanical injector for the precise delivery of liquids to target tissue.
Girish Chitnis,Girish Chitnis,M. K. S. Verma,M. K. S. Verma,Julien Lamazouade,Julien Lamazouade,Miguel Gonzalez-Andrades,Miguel Gonzalez-Andrades,Kisuk Yang,Ali Dergham,Ali Dergham,Peter A. Jones,Peter A. Jones,Benjamin E. Mead,Andrea Cruzat,Zhixiang Tong,Zhixiang Tong,Keir Martyn,Keir Martyn,Aniruddh Solanki,Aniruddh Solanki,Natalie Landon-Brace,Natalie Landon-Brace,Jeffrey M. Karp +23 more
TL;DR: A mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity can reliably and precisely deliver liquids to the suprachoroidal space, and to other injection-accessible target sites in the body.
Journal ArticleDOI
Cabozantinib Unlocks Efficient In Vivo Targeted Delivery of Neutrophil-Loaded Nanoparticles into Murine Prostate Tumors
Kiranj K. Chaudagar,Natalie Landon-Brace,Natalie Landon-Brace,Aniruddh Solanki,Aniruddh Solanki,Hanna M. Hieromnimon,Emma Hegermiller,Emma Hegermiller,Emma Hegermiller,Wen Li,Wen Li,Yue Shao,Yue Shao,John Joseph,Devan J. Wilkins,Devan J. Wilkins,Kaela Bynoe,Xiang-Ling Li,Xiang-Ling Li,John G. Clohessy,Soumya Ullas,Jeffrey M. Karp,Jeffrey M. Karp,Akash Patnaik +23 more
TL;DR: A novel targeted nano-immunotherapeutic strategy for enhanced intratumoral delivery of BSA-NPs, with translational potential to significantly augment therapeutic indices of cancer medicines, thereby overcoming current pharmacologic barriers commonly encountered in preclinical/early-phase drug development.
Posted ContentDOI
Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors
Kiranj K. Chaudagar,Natalie Landon-Brace,Aniruddh Solanki,Hanna M. Hieromnimon,Emma Hegermiller,Wen Li,Yue Shao,Devan J. Wilkins,Kaela Bynoe,Xiang-Ling Li,John G. Clohessy,Soumya Ullas,Jeffrey M. Karp,Akash Patnaik +13 more
TL;DR: A novel nano-immunotherapeutic strategy for enhanced intratumoral delivery of injected NPs, which results in significantly higher NP accumulation than reported strategies in the nanotechnology literature to-date is discovered.