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Nataliya Popovych
Researcher at Genentech
Publications - 18
Citations - 1715
Nataliya Popovych is an academic researcher from Genentech. The author has contributed to research in topics: Medicine & Catabolite activator protein. The author has an hindex of 11, co-authored 13 publications receiving 1511 citations. Previous affiliations of Nataliya Popovych include Rutgers University & University of Michigan.
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Journal ArticleDOI
Dynamically driven protein allostery.
TL;DR: It is shown that allostery can be mediated exclusively by transmitted changes in protein motions, and this work characterized the negatively cooperative binding of cAMP to the dimeric catabolite activator protein (CAP) at discrete conformational states.
Journal ArticleDOI
Role of Zinc in Human Islet Amyloid Polypeptide Aggregation
Jeffrey R. Brender,Kevin Hartman,Ravi Prakash Reddy Nanga,Nataliya Popovych,Roberto de la Salud Bea,Subramanian Vivekanandan,E. Neil G. Marsh,Ayyalusamy Ramamoorthy +7 more
TL;DR: The inhibition of the formation of aggregated and toxic forms of hIAPP by zinc provides a possible mechanism between the recent discovery of linkage between deleterious mutations in the SLC30A8 zinc transporter, which transports zinc into the secretory granule, and type II diabetes.
Journal ArticleDOI
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
Ingrid E. Wertz,Kim Newton,Dhaya Seshasayee,Saritha Kusam,Cynthia Lam,Juan Zhang,Nataliya Popovych,Elizabeth Helgason,Allyn J. Schoeffler,Surinder Jeet,Nandhini Ramamoorthi,Lorna Kategaya,Robert J. Newman,Keisuke Horikawa,Debra L. Dugger,Wendy Sandoval,Susmith Mukund,Anuradha Zindal,Flavius Martin,Clifford Quan,Jeffrey Tom,Wayne J. Fairbrother,Michael J. Townsend,Søren Warming,Jason DeVoss,Jinfeng Liu,Erin C. Dueber,Patrick Caplazi,Wyne P. Lee,Christopher C. Goodnow,Mercedesz Balazs,Kebing Yu,Ganesh Kolumam,Vishva M. Dixit +33 more
TL;DR: Molecular mechanisms whereby A20 deubiquitinase activity and ubiquitin binding, linear ubiquitination, and cellular kinases cooperate to regulate inflammation and cell death are revealed.
Journal ArticleDOI
Structural basis for cAMP-mediated allosteric control of the catabolite activator protein
TL;DR: The results define the structural mechanisms that underlie allosteric control of this prototypic transcriptional regulatory factor and provide an illustrative example of how effector-mediated structural changes can control the activity of regulatory proteins.
Journal ArticleDOI
A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data
Shivani Ahuja,Nicole Jahr,Sang Choul Im,Subramanian Vivekanandan,Nataliya Popovych,Stéphanie V. Le Clair,Rui Huang,Ronald Soong,Jiadi Xu,Kazutoshi Yamamoto,Ravi Prakash Reddy Nanga,Angela Bridges,Lucy Waskell,Ayyalusamy Ramamoorthy +13 more
TL;DR: The structure of the cytb5-cytP450 complex allows us to propose an interprotein electron transfer pathway involving the highly conserved Arg-125 on cytB5 serving as a salt bridge between the heme propionates of cytP450 and cytb 5.