Wendy Sandoval

TL;DR: Highlights suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics.

TL;DR: This study further illustrates the power of linking proteomic networks and human genetics to uncover critical disease pathways and identified ATXN10 and TCTN2 as new NPHP-JBTS genes, and the Tctn2 mouse knockout shows neural tube and Hedgehog signaling defects.

TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"

TL;DR: The complex that is described is essential for normal cilia function and acts as a diffusion barrier to maintain the cilia membrane as a compartmentalized signalling organelle.

TL;DR: In this article, the authors showed that the cell-surface NINJ1 protein, which contains two transmembrane regions, has an essential role in the induction of PMR.