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Nathalie Janel
Researcher at University of Paris
Publications - 90
Citations - 2661
Nathalie Janel is an academic researcher from University of Paris. The author has contributed to research in topics: Cystathionine beta synthase & Hyperhomocysteinemia. The author has an hindex of 25, co-authored 82 publications receiving 2253 citations. Previous affiliations of Nathalie Janel include Paris Diderot University & Roswell Park Cancer Institute.
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Journal ArticleDOI
Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
Rafael de la Torre,Susana Solá,Meritxell Pons,Arnaud Duchon,María Martínez de Lagrán,Magí Farré,Montserrat Fitó,Bessy Benejam,Klaus Langohr,Joan Rodríguez,Mitona Pujadas,Jean Charles Bizot,Aida Cuenca,Nathalie Janel,Silvina Catuara,María Isabel Covas,Henri Bléhaut,Yann Herault,Jean M. Delabar,Mara Dierssen +19 more
TL;DR: EGCG is a promising therapeutic tool for cognitive enhancement in DS, and its efficacy may depend of Dyrk1A inhibition, and plasma homocysteine levels are used as an efficacy biomarker in the human study.
Journal ArticleDOI
Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
Rafael de la Torre,Susana Solá,Gimena Hernandez,Magí Farré,Magí Farré,Jesús Pujol,Joan Rodríguez,Josep María Espadaler,Klaus Langohr,Aida Cuenca-Royo,Alessandro Principe,Laura Xicota,Nathalie Janel,Silvina Catuara-Solarz,Gonzalo Sanchez-Benavides,Henri Bléhaut,Iván Dueñas-Espín,Laura del Hoyo,Bessy Benejam,Laura Blanco-Hinojo,Sebastià Videla,Montserrat Fitó,Jean-Maurice Delabar,Jean-Maurice Delabar,Mara Dierssen +24 more
TL;DR: In this paper, the effects of green tea extract containing epigallocatechin-3-gallate (EGCG) on cognitive rehabilitation in young adults with Down's syndrome were investigated.
Journal ArticleDOI
Cystathionine β Synthase Deficiency Promotes Oxidative Stress, Fibrosis, and Steatosis in Mice Liver
Karine Robert,Johnny Nehme,Emmanuel Bourdon,Gérard Pivert,Bertrand Friguet,Claude Delcayre,Jean-Maurice Delabar,Nathalie Janel +7 more
TL;DR: The results show that hyperhomocysteinemia in liver of CBS-deficient mice promotes oxidative stress, which may cause mitochondrial damage in association with activation of hepatic stellate cells, leading to liver injury.
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Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
Martine Cohen-Salmon,Béatrice Regnault,Nadège Cayet,Dorothée Caille,K. Demuth,Jean-Pierre Hardelin,Nathalie Janel,Paolo Meda,Christine Petit +8 more
TL;DR: It is shown that the SV components of the EP electrogenic machinery and the epithelial barriers limiting the intrastrial fluid space, which are both necessary for the EP production, were preserved in Cx30−/− mice, while the endothelial barrier of the capillaries supplying the SV was disrupted before EP onset.
Journal ArticleDOI
Expression of the Cystathionine β Synthase (CBS) Gene During Mouse Development and Immunolocalization in Adult Brain
Karine Robert,François Vialard,Eric Thiery,Kiyoko Toyama,Kiyoko Toyama,Pierre-Marie Sinet,Pierre-Marie Sinet,Nathalie Janel,Jacqueline London +8 more
TL;DR: Investigation of the spatial and temporal patterns of Cbs gene expression during mouse development showed that the CBS protein was localized in most areas of the brain but predominantly in the cell bodies and neuronal processes of Purkinje cells and Ammon's horn neurons.