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Arnaud Duchon
Researcher at University of Strasbourg
Publications - 23
Citations - 1048
Arnaud Duchon is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Chromosome 21 & Trisomy. The author has an hindex of 11, co-authored 19 publications receiving 873 citations. Previous affiliations of Arnaud Duchon include French Institute of Health and Medical Research.
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Journal ArticleDOI
Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans
Rafael de la Torre,Susana Solá,Meritxell Pons,Arnaud Duchon,María Martínez de Lagrán,Magí Farré,Montserrat Fitó,Bessy Benejam,Klaus Langohr,Joan Rodríguez,Mitona Pujadas,Jean Charles Bizot,Aida Cuenca,Nathalie Janel,Silvina Catuara,María Isabel Covas,Henri Bléhaut,Yann Herault,Jean M. Delabar,Mara Dierssen +19 more
TL;DR: EGCG is a promising therapeutic tool for cognitive enhancement in DS, and its efficacy may depend of Dyrk1A inhibition, and plasma homocysteine levels are used as an efficacy biomarker in the human study.
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Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
Arnaud Duchon,Matthieu Raveau,Claire Chevalier,Valérie Nalesso,Andrew J. Sharp,Yann Herault,Yann Herault +6 more
TL;DR: Using a comparative genomic approach, this work has been able to locate precisely the translocation breakpoint in these two models and took advantage of this finding to derive a new and more efficient Ts65Dn genotyping strategy.
Journal ArticleDOI
Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice:
J. Braudeau,J. Braudeau,Benoît Delatour,Benoît Delatour,Arnaud Duchon,P. Lopes Pereira,Luce Dauphinot,F. de Chaumont,Jean-Christophe Olivo-Marin,Robert H. Dodd,Yann Herault,Marie-Claude Potier +11 more
TL;DR: It is demonstrated that α5IA restores learning and memory functions of Ts65Dn mice in the novel-object recognition and in the Morris water maze tasks and enhances learning-evoked immediate early gene products in specific brain regions involved in cognition following behavioural stimulation.
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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage.
Benoit Souchet,Faycal Guedj,Ignasi Sahún,Arnaud Duchon,Fabrice Daubigney,Anne Badel,Yuchio Yanagawa,Maria Jose Barallobre,Mara Dierssen,Eugene Yu,Yann Herault,M.L. Arbonés,Nathalie Janel,Nicole Créau,Jean-Maurice Delabar +14 more
TL;DR: This study shows that DYRK1A overexpression affects pathways involved in synaptogenesis and synaptic plasticity and influences E/I balance toward inhibition and its inhibition/activation may also be relevant for other psychiatric diseases with E-I balance alterations.
Journal ArticleDOI
Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
Benoit Souchet,Faycal Guedj,Faycal Guedj,Zsuza Penke-Verdier,Fabrice Daubigney,Arnaud Duchon,Yann Herault,Jean-Charles Bizot,Nathalie Janel,Nicole Créau,Benoît Delatour,Jean Maurice Delabar,Jean Maurice Delabar +12 more
TL;DR: The results indicate that excessive synaptic inhibition in people with DS may be attributable, in large part, to increased Dyrk1A dosage, and controlling the level of active DYRK1A is a clear issue for DS therapy.