D
Dorothée Caille
Researcher at University of Geneva
Publications - 39
Citations - 3415
Dorothée Caille is an academic researcher from University of Geneva. The author has contributed to research in topics: Pancreatic islets & Connexin. The author has an hindex of 28, co-authored 39 publications receiving 3186 citations. Previous affiliations of Dorothée Caille include Carnegie Mellon University & National University of Singapore.
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Journal ArticleDOI
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
Abigail Woodfin,Mathieu-Benoit Voisin,Martina Beyrau,Bartomeu Colom,Dorothée Caille,Frantzeska-Maria Diapouli,Gerard B. Nash,Triantafyllos Chavakis,Steven M. Albelda,G. Ed Rainger,Paolo Meda,Beat A. Imhof,Sussan Nourshargh +12 more
TL;DR: The results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation.
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Loss of connexin36 channels alters beta-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release.
Magalie A. Ravier,Martin Güldenagel,Anne Charollais,Asllan Gjinovci,Dorothée Caille,Goran Söhl,Claes B. Wollheim,Klaus Willecke,Jean-Claude Henquin,Paolo Meda +9 more
TL;DR: Data show that Cx36-dependent signaling is essential for the proper functioning of beta-cells, particularly for the pulsatility of [Ca(2+)](i) and insulin secretion during glucose stimulation.
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Rhamnolipids Are Virulence Factors That Promote Early Infiltration of Primary Human Airway Epithelia by Pseudomonas aeruginosa
Laurence Zulianello,Coralie Canard,Thilo Köhler,Dorothée Caille,Jean-Silvain Lacroix,Paolo Meda +5 more
TL;DR: The study provides direct evidence for a hitherto unknown mechanism whereby the junction-dependent barrier of the respiratory epithelium is selectively altered by rhamnolipid-deficient P. aeruginosa.
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Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
Grzegorz Sumara,Ivan Formentini,Stephan C. Collins,Izabela Sumara,Renata Windak,Bernd Bodenmiller,Bernd Bodenmiller,Reshma Ramracheya,Dorothée Caille,Huiping Jiang,Kenneth A. Platt,Paolo Meda,Rudolf Aebersold,Patrik Rorsman,Romeo Ricci +14 more
TL;DR: It is shown that mice lacking the mitogen-activated protein kinase (MAPK) p38δ display improved glucose tolerance due to enhanced insulin secretion from pancreatic β cells, pointing to a pivotal role for this pathway in the development of overt diabetes mellitus.
Journal ArticleDOI
Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice
E. Roggli,Sonia Gattesco,Dorothée Caille,Claire Briet,Christian Boitard,Paolo Meda,Romano Regazzi +6 more
TL;DR: It is suggested that changes in the level of miR-29 family members contribute to cytokine-mediated β-cell dysfunction occurring during the initial phases of type 1 diabetes.