N
Nathalie Jullian
Researcher at French Institute of Health and Medical Research
Publications - 34
Citations - 935
Nathalie Jullian is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Zinc finger & Transfer RNA. The author has an hindex of 13, co-authored 30 publications receiving 902 citations.
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Journal ArticleDOI
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
Nelly Morellet,Nathalie Jullian,H. de Rocquigny,B Maigret,Jean-Luc Darlix,Bernard-Pierre Roques +5 more
TL;DR: The proposed structure of NCp7 might be used to rationally design new anti‐viral agents aimed at inhibiting its functions, as well as to study its various biological properties.
Journal ArticleDOI
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR
Nelly Morellet,H. de Rocquigny,Yves Mély,Nathalie Jullian,Hélène Déméné,M. Ottmann,Dominique Gerard,Jean-Luc Darlix,Marie-Claude Fournie-Zaluski,Bernard-Pierre Roques +9 more
TL;DR: The results suggest that the spatial proximity of the zinc fingers induced by the peptide linker, plays a critical role in encapsidation of genomic RNA and morphogenesis of HIV-1 infectious particles.
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1H NMR structure and biological studies of the His23 .fwdarw. Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity
Hélène Déméné,Chang-Zhi Dong,M. Ottmann,M. C. Rouyez,Nathalie Jullian,Nelly Morellet,Y. Mely,Jean-Luc Darlix,Marie-Claude Fournie-Zaluski +8 more
TL;DR: It is suggested that a bona fide conformation of the HIV-1 NCp7 is critical for the packaging of viral RNA, its stability in virions, and virus infectivity.
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New Dual Inhibitors of Neutral Endopeptidase and Angiotensin-Converting Enzyme: Rational Design, Bioavailability, and Pharmacological Responses in Experimental Hypertension
Marie-Claude Fournie-Zaluski,Pascale Coric,Serge Turcaud,Nathalie Rousselet,Walter D. Gonzalez,Brigitte Barbe,Isabelle Pham,Nathalie Jullian,Jean-Baptiste Michel,Bernard P. Roques +9 more
TL;DR: The separation of the four stereoisomers using chiral amines and the stereoselective synthesis of the 2-(mercaptomethyl)-3-phenylbutanoyl moiety showed that inhibitors with the 2S,3R configuration are the most potent on both NEP and ACE.
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Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation
TL;DR: To investigate the structural requirements for selective activation or blockade of metabotropic glutamate receptors, a pharmacophore model for group I (mGluR1) and group II (m GluR2) agonists is developed and shows that the selectivity between mGlu R1 and mGLUR2 subtypes may be due to excluded volumes and additional binding sites, while the relative spatial position of functional groups remains very similar.