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Nelita du Plessis
Researcher at South African Medical Research Council
Publications - 48
Citations - 1312
Nelita du Plessis is an academic researcher from South African Medical Research Council. The author has contributed to research in topics: Tuberculosis & Medicine. The author has an hindex of 14, co-authored 37 publications receiving 842 citations. Previous affiliations of Nelita du Plessis include DST Systems & Stellenbosch University.
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Journal ArticleDOI
Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
Simon Tiberi,Nelita du Plessis,Gerhard Walzl,Michael J. Vjecha,Martin Rao,Francine Ntoumi,Sayoki Mfinanga,Nathan Kapata,Peter Mwaba,Timothy D. McHugh,Giuseppe Ippolito,Giovanni Battista Migliori,Markus Maeurer,Alimuddin Zumla +13 more
TL;DR: The developmental pipeline and landscape of new and repurposed tuberculosis drugs, treatment regimens, and host-directed therapies (HDTs) for drug-sensitive and drug-resistant tuberculosis are reviewed and a range of HDTs and immune-based treatments are under investigation as adjunctive therapy.
Journal ArticleDOI
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Gerhard Walzl,Gerhard Walzl,Ruth McNerney,Nelita du Plessis,Nelita du Plessis,Matthew Bates,Matthew Bates,Timothy D. McHugh,Novel N. Chegou,Novel N. Chegou,Alimuddin Zumla,Alimuddin Zumla +11 more
TL;DR: G gaps and challenges in evaluation and rollout of new diagnostics and biomarkers are highlighted, and areas needing further investment are prioritised, including impact assessment and cost-benefit studies.
Journal ArticleDOI
Increased Frequency of Myeloid-derived Suppressor Cells during Active Tuberculosis and after Recent Mycobacterium tuberculosis Infection Suppresses T-Cell Function
Nelita du Plessis,Laurianne Loebenberg,Magdalena Kriel,Florian von Groote-Bidlingmaier,Eliana Ribechini,Andre G. Loxton,Paul D. van Helden,Manfred B. Lutz,Gerhard Walzl +8 more
TL;DR: Data reveal that innate MDSCs are induced not only during active TB at similar levels as found in cancer, but also in healthy individuals after recent exposure to M.tb.
Journal ArticleDOI
Monocytic Myeloid-Derived Suppressor Cells in Chronic Infections.
Anca Dorhoi,Nelita du Plessis +1 more
TL;DR: The roles of M-MDSC in infections, including opportunistic extracellular bacteria and fungi as well as persistent intracellular pathogens, such as mycobacteria and certain viruses, are focused on.
Journal ArticleDOI
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis
Ninecia R. Scott,Rosemary V. Swanson,Noor Al-Hammadi,Racquel Domingo-Gonzalez,Javier Rangel-Moreno,Belinda Kriel,Allison N. Bucsan,Shibali Das,Mushtaq Ahmed,Smriti Mehra,Puthayalai Treerat,Alfredo Cruz-Lagunas,Luis Jiménez-Alvarez,Marcela Muñoz-Torrico,Karen Bobadilla-Lozoya,Thomas Vogl,Gerhard Walzl,Nelita du Plessis,Deepak Kaushal,Thomas J. Scriba,Thomas J. Scriba,Joaquín Zúñiga,Shabaana A. Khader +22 more
TL;DR: Using the well-established mouse model of TB, new data provides evidence that the alarmin S100A8/A9 mediates neutrophil accumulation during progression to chronic TB, and supports targeting S 100A8-A9 pathways as host-directed therapy for TB.