N
Nerges Winblad
Researcher at McGovern Institute for Brain Research
Publications - 4
Citations - 876
Nerges Winblad is an academic researcher from McGovern Institute for Brain Research. The author has contributed to research in topics: CRISPR/Cpf1 & Trans-activating crRNA. The author has an hindex of 4, co-authored 4 publications receiving 587 citations.
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Journal ArticleDOI
Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Jeroen Kneppers,Ellen M DeGennaro,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,David A. Scott,Konstantin Severinov,Konstantin Severinov,Konstantin Severinov,John van der Oost,Feng Zhang +19 more
TL;DR: It is shown that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing.
Posted ContentDOI
Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,Konstantin Severinov,John van der Oost,Feng Zhang +14 more
TL;DR: This work shows for two Cpf1 orthologs that no other factors are required for array processing and demonstrates multiplex gene editing in mammalian cells as well as in the mouse brain by using a designed single CRISPR array.
Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Jeroen Kneppers,Ellen M DeGennaro,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,David A. Scott,Konstantin Severinov,Konstantin Severinov,Konstantin Severinov,John van der Oost,Feng Zhang +19 more
TL;DR: In the version of this article initially published, the percentage for the targets Mecp2, Nlgn3, and Drd1 should be 15.2%, not 16.9%; the same error appeared in the main text, next to last paragraph, “The authors' results show that ∼17%.
Journal ArticleDOI
Erratum: Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array.
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,Konstantin Severinov,John van der Oost,Feng Zhang +14 more
TL;DR: In this article, the percentage for the targets Mecp2, Nlgn3, and Drd1 should have been 15.2%, not 16.9%; the same error appeared in the main text, next to last paragraph, “Our results show that ∼17%.