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Iana Fedorova
Researcher at Skolkovo Institute of Science and Technology
Publications - 9
Citations - 930
Iana Fedorova is an academic researcher from Skolkovo Institute of Science and Technology. The author has contributed to research in topics: CRISPR & Cas9. The author has an hindex of 6, co-authored 9 publications receiving 614 citations. Previous affiliations of Iana Fedorova include Saint Petersburg State Polytechnic University & McGovern Institute for Brain Research.
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Journal ArticleDOI
Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Jeroen Kneppers,Ellen M DeGennaro,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,David A. Scott,Konstantin Severinov,Konstantin Severinov,Konstantin Severinov,John van der Oost,Feng Zhang +19 more
TL;DR: It is shown that the ability of Cpf1 to process its own CRISPR RNA (crRNA) can be used to simplify multiplexed genome editing.
Posted ContentDOI
Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,Konstantin Severinov,John van der Oost,Feng Zhang +14 more
TL;DR: This work shows for two Cpf1 orthologs that no other factors are required for array processing and demonstrates multiplex gene editing in mammalian cells as well as in the mouse brain by using a designed single CRISPR array.
Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Jeroen Kneppers,Ellen M DeGennaro,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,David A. Scott,Konstantin Severinov,Konstantin Severinov,Konstantin Severinov,John van der Oost,Feng Zhang +19 more
TL;DR: In the version of this article initially published, the percentage for the targets Mecp2, Nlgn3, and Drd1 should be 15.2%, not 16.9%; the same error appeared in the main text, next to last paragraph, “The authors' results show that ∼17%.
Journal ArticleDOI
Erratum: Multiplex gene editing by CRISPR-Cpf1 using a single crRNA array.
Bernd Zetsche,Matthias Heidenreich,Prarthana Mohanraju,Iana Fedorova,Jeroen Kneppers,Ellen M DeGennaro,Nerges Winblad,Sourav R Choudhury,Omar O. Abudayyeh,Jonathan S. Gootenberg,Wen Y Wu,David A. Scott,Konstantin Severinov,John van der Oost,Feng Zhang +14 more
TL;DR: In this article, the percentage for the targets Mecp2, Nlgn3, and Drd1 should have been 15.2%, not 16.9%; the same error appeared in the main text, next to last paragraph, “Our results show that ∼17%.
Journal ArticleDOI
Detection of spacer precursors formed in vivo during primed CRISPR adaptation.
Anna A. Shiriaeva,Anna A. Shiriaeva,Anna A. Shiriaeva,Ekaterina Savitskaya,Ekaterina Savitskaya,Kirill A. Datsenko,Irina O. Vvedenskaya,Iana Fedorova,Iana Fedorova,Natalia Morozova,Natalia Morozova,Anastasia Metlitskaya,Anton Sabantsev,Bryce E. Nickels,Konstantin Severinov,Ekaterina Semenova +15 more
TL;DR: A method for strand-specific, high-throughput sequencing of DNA fragments, FragSeq, is developed and applied to identify DNA fragments accumulated in Escherichia coli cells undergoing robust primed adaptation by a type I-E ortype I-F CRISPR-Cas system.