Neta Rosenzweig

TL;DR: It is demonstrated that the route of monocyte entry to central nervous system provides an instructional environment to shape their function, and the homing of proinflammatory and anti-inflammatory macrophages to traumatized spinal cord was distinctly regulated.

TL;DR: It is shown that transient depletion of Foxp3+ regulatory T cells (Tregs), or pharmacological inhibition of their activity, is followed by amyloid-β plaque clearance, mitigation of the neuroinflammatory response and reversal of cognitive decline in AD.

TL;DR: Using mouse models of Alzheimer's disease, it is shown that immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway evokes an interferon-γ–dependent systemic immune response, which is followed by the recruitment of monocyte-derived macrophages to the brain.

TL;DR: These findings attribute a novel immunological plasticity to the choroid plexus epithelium, allowing it to serve, through interferon-γ signalling, as a tightly regulated entry gate into the central nervous system for circulating leucocytes immune surveillance under physiological conditions, and for repair following acute injury.

TL;DR: It is shown that the chronic presence of type I interferon in aged mouse brain impedes cognitive ability by altering microglia transcriptome and limiting Mef2C, a microglial ‘off’ signal.