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Newman Siu Kwan Sze
Researcher at Nanyang Technological University
Publications - 10
Citations - 2024
Newman Siu Kwan Sze is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Phosphorylation & Exosome. The author has an hindex of 6, co-authored 8 publications receiving 1695 citations. Previous affiliations of Newman Siu Kwan Sze include Agency for Science, Technology and Research.
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Journal ArticleDOI
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Ruenn Chai Lai,Fatih Arslan,May May Lee,Newman Siu Kwan Sze,Andre Choo,Tiansheng Chen,Manuel Salto-Tellez,Leo Timmers,Chuen Neng Lee,Reida El Oakley,Gerard Pasterkamp,Dominique P.V. de Kleijn,Sai Kiang Lim +12 more
TL;DR: The novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
Book ChapterDOI
Mesenchymal Stem Cell Exosomes: The Future MSC-Based Therapy?
Ruenn Chai Lai,Ronne Wee Yeh Yeo,Ronne Wee Yeh Yeo,Soon Sim Tan,Bin Zhang,Yijun Yin,Newman Siu Kwan Sze,Andre Choo,Sai Kiang Lim +8 more
TL;DR: The exosome, a secreted membrane vesicle, is identified, as an active therapeutic factor in MSC secretion, and could potentially underpin the therapeutic efficacy of MSC in diverse disease indications.
Journal ArticleDOI
Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.
Yunhao Chen,Teck-Yew Low,Teck-Yew Low,Lee Yee Choong,Rajarshi Ray,Yee-Ling Tan,Weiyi Toy,Qingsong Lin,Boon Keong Ang,Chee Hong Wong,Simin Lim,Bin Li,Choy L. Hew,Newman Siu Kwan Sze,Newman Siu Kwan Sze,Brian J. Druker,Yoon Pin Lim,Yoon Pin Lim +17 more
TL;DR: This study is the first to identify and validate Endofin, DCBLD2, and KIAA0582 as part of a complex EGF phosphotyrosine signaling network and will provide new insights into thecomplex EGF signaling and may have implications on target‐directed cancer therapeutics.
Journal ArticleDOI
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Irene Chengjie Lee,Xue Yan Ho,Simi Elizabeth George,Catherine Wenhui Goh,Jeyapriya Rajameenakshi Sundaram,Karen Ka Lam Pang,Weiwei Luo,Permeen Yusoff,Newman Siu Kwan Sze,Shirish Shenolikar,Shirish Shenolikar +10 more
TL;DR: A novel role for the GADD34/PP1α complex in coordinating the dephosphorylation and reactivation of eIF2α and SIRT1 to determine cell fate following oxidative stress is highlighted.
Journal ArticleDOI
Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration
Catherine Wenhui Goh,Irene Chengjie Lee,Jeyapriya Rajameenakshi Sundaram,Simi Elizabeth George,Permeen Yusoff,Matthew H. Brush,Newman Siu Kwan Sze,Shirish Shenolikar,Shirish Shenolikar +8 more
TL;DR: It is reported that arsenite-induced oxidative stress differs from thapsigargin- or tunicamycin-induced ER stress in promoting GADD34 transcription and the preferential translation of its mRNA in the absence of eIF2α phosphorylation.