N
Nicholas M. Croft
Researcher at Queen Mary University of London
Publications - 84
Citations - 3747
Nicholas M. Croft is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Inflammatory bowel disease & Ulcerative colitis. The author has an hindex of 25, co-authored 71 publications receiving 2943 citations. Previous affiliations of Nicholas M. Croft include Royal Hospital for Sick Children & University College London.
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Journal ArticleDOI
Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease
Giovanni Monteleone,Andrea Kumberova,Nicholas M. Croft,Catriona McKenzie,Howard W. Steer,Thomas T. MacDonald +5 more
TL;DR: It is shown that Smad7 blockade of TGF-beta1 signaling helps maintain the chronic production of proinflammatory cytokines that drives the inflammatory process in IBD and that inhibition of Smad 7 enables endogenous TGF -beta to downregulate this response.
Journal ArticleDOI
Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study
Nicholas A. Kennedy,Nicholas A. Kennedy,Nicholas A. Kennedy,Graham A. Heap,Harry D Green,Benjamin Hamilton,Claire Bewshea,Gareth J. Walker,Amanda Thomas,Rachel Nice,Mandy H Perry,Sonia Bouri,Neil Chanchlani,Neel Heerasing,Peter Hendy,Simeng Lin,Daniel R. Gaya,J R Fraser Cummings,J R Fraser Cummings,Christian P. Selinger,Charlie W. Lees,Charlie W. Lees,Ailsa L. Hart,Miles Parkes,Shaji Sebastian,John C Mansfield,Peter M. Irving,James O. Lindsay,Richard K Russell,Timothy J. McDonald,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie W. Lees,Gareth R. Jones,James W Hart,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil Shah,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C. Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +160 more
TL;DR: Clinical and pharmacokinetic factors that predict primary non-response at week 14 after starting treatment, non-remission at week 54, and adverse events leading to drug withdrawal are identified.
Journal ArticleDOI
Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.
Dan Turner,Frank M. Ruemmele,Esther Orlanski-Meyer,Anne M. Griffiths,Javier Martín de Carpi,Jiri Bronsky,Gábor Veres,Marina Aloi,Caterina Strisciuglio,Christian Braegger,Amit Assa,Claudio Romano,Seamus Hussey,Michael Stanton,Mikko P. Pakarinen,Lissy de Ridder,Konstantinos H. Katsanos,Nicholas M. Croft,Víctor Manuel Navas-López,David C. Wilson,Sally Lawrence,Richard K. Russell +21 more
TL;DR: These guidelines provide a guide to clinicians managing children with UC and IBD-unclassified management to provide modern management strategies while maintaining vigilance around appropriate outcomes and safety issues.
Journal ArticleDOI
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease
Aleksejs Sazonovs,Nicholas A Kennedy,Nicholas A Kennedy,Loukas Moutsianas,Graham A. Heap,Graham A. Heap,Daniel L. Rice,Mark Reppell,Claire Bewshea,Neil Chanchlani,Neil Chanchlani,Gareth J. Walker,Gareth J. Walker,Mandy H Perry,Timothy J. McDonald,Charlie W. Lees,J R Fraser Cummings,J R Fraser Cummings,Miles Parkes,John C. Mansfield,Peter M. Irving,Jeffrey C. Barrett,Dermot P.B. McGovern,James R Goodhand,James R Goodhand,Carl A. Anderson,Tariq Ahmad,Tariq Ahmad,Vinod B. Patel,Zia Mazhar,Rebecca Saich,Ben Colleypriest,Tony C.K. Tham,Tariq Iqbal,Vishal Kaushik,Senthil V. Murugesan,Salil Singh,Sean Weaver,Cathryn Preston,Assad Butt,Melissa A. Smith,Dharamveer Basude,Amanda Beale,Sarah Langlands,Natalie C. Direkze,Franco Torrente,Juan De La Revella Negro,Christopher Macdonald,Stephen M. Evans,Anton V J Gunasekera,Alka Thakur,David A Elphick,Achuth Shenoy,Chuka U. Nwokolo,Anjan Dhar,Andrew T. Cole,Anurag Agrawal,Stephen Bridger,Julie Doherty,Sheldon C. Cooper,Shanika de Silva,Craig Mowat,Phillip Mayhead,Charlie Lees,Gareth T. Jones,James W Hart,Daniel R. Gaya,Richard K. Russell,Lisa Gervais,Paul Dunckley,Tariq Mahmood,Paul R. Banim,Sunil Sonwalkar,Deb Ghosh,Rosemary H Phillips,Amer Azaz,Shaji Sebastian,Richard Shenderey,Lawrence Armstrong,Claire Bell,Radhakrishnan Hariraj,Helen Matthews,Hasnain Jafferbhoy,Christian P. Selinger,Veena Zamvar,John de Caestecker,Anne Willmott,Richard A. Miller,Palani Sathish Babu,Christos Tzivinikos,Stuart Bloom,Guy Chung-Faye,Nicholas M. Croft,John Fell,Marcus Harbord,Ailsa Hart,Ben Hope,James O. Lindsay,Joel Mawdsley,Alistair McNair,Kevin J. Monahan,Charles Murray,Timothy R. Orchard,Thankam Paul,Richard Pollok,Neil P. Shah,Sonia Bouri,Matthew W. Johnson,Anita Modi,Kasamu Dawa Kabiru,B K Baburajan,Bim Bhaduri,Andrew A. Fagbemi,Scott Levison,Jimmy K. Limdi,Gill Watts,Stephen Foley,Arvind Ramadas,George MacFaul,John C Mansfield,Leonie Grellier,Mary-Anne Morris,Mark Tremelling,Christopher J. Hawkey,Sian Kirkham,Charles Pj Charlton,Astor Rodrigues,Alison Simmons,Stephen Lewis,Jonathon Snook,Mark Tighe,Patrick Goggin,Aminda De Silva,Simon Lal,Mark S. Smith,Simon Panter,Fraser Cummings,Suranga Dharmisari,M J Carter,David Watts,Zahid Mahmood,Bruce McLain,Sandip Sen,Anna J Pigott,David Hobday,Emma Wesley,R B Johnston,Cathryn Edwards,John Beckly,Deven Vani,Subramaniam Ramakrishnan,Rakesh Chaudhary,Nigel Trudgill,Rachel Cooney,Andrew Bell,Neeraj Prasad,John N. Gordon,Matthew J Brookes,Andy Li,Stephen Gore +159 more
TL;DR: In an observational study, a genome-wide significant association between HLA-DQA1*05 and the development of antibodies against anti-TNF agents is found and a randomized controlled biomarker trial is required to determine whether pretreatment testing for HLA*05 improves patient outcomes by helping physicians select anti- TNF and combination therapies.
Journal ArticleDOI
Anti-inflammatory and growth-stimulating effects precede nutritional restitution during enteral feeding in Crohn disease.
Kaushik Bannerjee,Cecilia Camacho-Hübner,Katarzyna Babinska,Kay M Dryhurst,Ray Edwards,Martin O. Savage,Ian R. Sanderson,Nicholas M. Croft +7 more
TL;DR: Early increases in IGF-I during treatment of Crohn disease are attributable to the anti-inflammatory effect of the enteral feed rather than nutritional restitution.