N
Nick Curzen
Researcher at University of Southampton
Publications - 376
Citations - 13705
Nick Curzen is an academic researcher from University of Southampton. The author has contributed to research in topics: Percutaneous coronary intervention & Myocardial infarction. The author has an hindex of 46, co-authored 312 publications receiving 11050 citations. Previous affiliations of Nick Curzen include Lincoln County Hospital & James Cook University Hospital.
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Journal ArticleDOI
Fractional flow reserve-guided PCI versus medical therapy in stable coronary disease
Bernard De Bruyne,Bindu Kalesan,Emanuele Barbato,Zsolt Piroth,Nikola Jagic,Sven Mobius-Winckler,Gilles Rioufol,Nils Witt,Petr Kala,Philip MacCarthy,Thomas Engstrøm,Keith G. Oldroyd,Kreton Mavromatis,Ganesh Manoharan,Peter Verlee,Ole Fröbert,Nick Curzen,Jane B. Johnson,Peter Jüni,William F. Fearon,Trial Investigators +20 more
TL;DR: In patients with stable coronary artery disease and functionally significant stenoses, FFR-guided PCI plus the best available medical therapy, as compared with the best Available medical therapy alone, decreased the need for urgent revascularization.
Journal ArticleDOI
Fractional Flow Reserve–Guided PCI for Stable Coronary Artery Disease
Bernard De Bruyne,William F. Fearon,Nico H.J. Pijls,Emanuele Barbato,Pim A.L. Tonino,Zsolt Piroth,Nikola Jagic,Sven Mobius-Winckler,Gilles Rioufol,Nils Witt,Petr Kala,Philip MacCarthy,Thomas Engstrøm,Keith G. Oldroyd,Kreton Mavromatis,Ganesh Manoharan,Peter Verlee,Ole Fröbert,Nick Curzen,Jane B. Johnson,Andreas Limacher,Eveline Nüesch,Peter Jüni +22 more
TL;DR: In patients with stable coronary artery disease, FFR-guided PCI, as compared with medical therapy alone, improved the outcome and was significantly lower in the PCI group than in the medical-therapy group.
Journal ArticleDOI
Randomized trial of complete versus lesion-only revascularization in patients undergoing primary percutaneous coronary intervention for STEMI and multivessel disease: the CvLPRIT trial
Anthony H. Gershlick,Jamal N Khan,Damian J. Kelly,John P Greenwood,Thiagarajah Sasikaran,Nick Curzen,Daniel J. Blackman,Miles Dalby,Kathryn L. Fairbrother,Winston Banya,Duolao Wang,Marcus Flather,Simon Hetherington,Andrew Kelion,Suneel Talwar,Mark Gunning,Roger Hall,Howard Swanton,Gerry P McCann +18 more
TL;DR: In patients presenting for P-PCI with multivessel disease, index admission complete revascularization significantly lowered the rate of the composite primary endpoint at 12 months compared with treating only the IRA.
Journal ArticleDOI
Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFRCT: outcome and resource impacts study
Pamela S. Douglas,Gianluca Pontone,Mark A. Hlatky,Manesh R. Patel,Bjarne L. Nørgaard,Robert A. Byrne,Nick Curzen,Ian Purcell,Matthias Gutberlet,Gilles Rioufol,Ulrich Hink,Herwig Schuchlenz,Gudrun Feuchtner,Martine Gilard,Daniele Andreini,Jesper M. Jensen,Martin Hadamitzky,Karen Chiswell,Derek D. Cyr,Alan Wilk,Furong Wang,Campbell Rogers,Bernard De Bruyne +22 more
TL;DR: Computed tomographic angiography/fractional flow reserve by CTA was a feasible and safe alternative to ICA and was associated with a significantly lower rate of invasive Angiography showing no obstructive CAD.
Journal ArticleDOI
Randomized Trial of Simple Versus Complex Drug-Eluting Stenting for Bifurcation Lesions. The British Bifurcation Coronary Study: Old, New, and Evolving Strategies
David Hildick-Smith,Adam de Belder,Nina Cooter,Nick Curzen,Tim Clayton,Keith G. Oldroyd,Lorraine Bennett,Steve Holmberg,James Cotton,Peter E. Glennon,Martyn Thomas,Philip MacCarthy,Andreas Baumbach,Niall T. Mulvihill,Robert A. Henderson,Simon Redwood,Ian R. Starkey,Rodney H. Stables +17 more
TL;DR: When coronary bifurcation lesions are treated, a systematic 2-stent technique results in higher rates of in-hospital and 9-month major adverse cardiovascular events, largely driven by periprocedural myocardial infarction.