N
Nick Tyler
Researcher at University College London
Publications - 140
Citations - 4559
Nick Tyler is an academic researcher from University College London. The author has contributed to research in topics: Public transport & Population. The author has an hindex of 20, co-authored 135 publications receiving 4049 citations. Previous affiliations of Nick Tyler include University College London Hospitals NHS Foundation Trust.
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Journal ArticleDOI
Effect of gene therapy on visual function in Leber's congenital amaurosis.
James W B Bainbridge,Alexander J. Smith,Susie S Barker,Scott J Robbie,Robert H. Henderson,Kamaljit S. Balaggan,Ananth C. Viswanathan,Graham E. Holder,Andrew Stockman,Nick Tyler,Simon M. Petersen-Jones,Shomi S. Bhattacharya,Adrian J. Thrasher,Fred W. Fitzke,Barrie J Carter,Gary S. Rubin,Anthony T. Moore,Robin R. Ali +17 more
TL;DR: Three young adult patients with early-onset, severe retinal dystrophy were administered subretinal injections of recombinant adeno-associated virus vector 2/2 expressing RPE65 complementary DNA (cDNA) under the control of a human R PE65 promoter.
Journal ArticleDOI
Long-Term Effect of Gene Therapy on Leber’s Congenital Amaurosis
James W B Bainbridge,James W B Bainbridge,Manjit S Mehat,Venki Sundaram,Scott J Robbie,S. E. Barker,Caterina Ripamonti,Anastasios Georgiadis,Anastasios Georgiadis,Freya M. Mowat,Freya M. Mowat,Stuart G Beattie,Peter Gardner,Kecia L. Feathers,Vy Luong,Suzanne Yzer,Kamaljit S. Balaggan,Kamaljit S. Balaggan,Ananth C. Viswanathan,Thomy de Ravel,Ingele Casteels,Graham E. Holder,Nick Tyler,Fred W. Fitzke,Richard G. Weleber,Marko Nardini,Marko Nardini,Anthony T. Moore,Anthony T. Moore,Debra A. Thompson,Simon M. Petersen-Jones,Michel Michaelides,Michel Michaelides,L. Ingeborgh van den Born,Andrew Stockman,Alexander J. Smith,Gary S. Rubin,Robin R. Ali,Robin R. Ali +38 more
TL;DR: In dogs, RPE65 gene therapy with the same vector at lower doses improved vision-guided behavior, but only higher doses resulted in improvements in retinal function that were detectable with the use of ERG, and comparison with the results obtained in the dog model indicates that there is a species difference in the amount of R PE65 required to drive the visual cycle.
Journal ArticleDOI
Culture and health
A. David Napier,Clyde Ancarno,Beverley Butler,Joseph D. Calabrese,Angel M. Chater,Helen J. Chatterjee,François Guesnet,Rob Horne,Stephen Jacyna,Sushrut Jadhav,Alison Macdonald,Ulrike Neuendorf,Aaron Parkhurst,Rodney Reynolds,Graham Scambler,Sonu Shamdasani,Sonia Zafer Smith,Jakob Stougaard-Nielsen,Linda Thomson,Nick Tyler,Anna-Maria Volkmann,Trinley Walker,Jessica Watson,Amanda C de C Williams,Chris Willott,James F. Wilson,Katherine Woolf +26 more
TL;DR: In this paper, the authors argue that the perceived distinction between the objectivity of science and the subjectivity of culture is itself a social fact (a common perception) and attribute the absence of awareness of the cultural dimensions of scientific practice to this distinction, especially for macrocultures and large societies.
Journal ArticleDOI
The Automatic Detection of Chronic Pain-Related Expression: Requirements, Challenges and the Multimodal EmoPain Dataset
M.S.H. Aung,Sebastian Kaltwang,Bernardino Romera-Paredes,Brais Martinez,Aneesha Singh,Matteo Cella,Michel Valstar,Hongying Meng,Andrew Kemp,Moshen Shafizadeh,Aaron C. Elkins,Natalie Kanakam,Amschel de Rothschild,Nick Tyler,Paul J. Watson,Amanda C de C Williams,Maja Pantic,Nadia Bianchi-Berthouze +17 more
TL;DR: The factors and challenges in the automated recognition of such expressions and behaviour are described and potential avenues for development of such systems are discussed by discussing potential avenues in the context of these findings.
Journal ArticleDOI
Influence of Platform Height, Door Width, and Fare Collection on Bus Dwell Time: Laboratory Evidence for Santiago de Chile
TL;DR: Results of dwell time parameters obtained from real-scale experiments made at the Pedestrian Accessibility and Movement Environment Laboratory, University College London indicate that door width has more influence than platform height.